Version 1
: Received: 11 May 2024 / Approved: 13 May 2024 / Online: 13 May 2024 (13:22:32 CEST)
How to cite:
Nikpay, M. Multiomics Data Analyses Identified CpG Sites and Genes That Mediate the Impact of Exposure to Environmental Chemicals on Cardiometabolic Traits. Preprints2024, 2024050849. https://doi.org/10.20944/preprints202405.0849.v1
Nikpay, M. Multiomics Data Analyses Identified CpG Sites and Genes That Mediate the Impact of Exposure to Environmental Chemicals on Cardiometabolic Traits. Preprints 2024, 2024050849. https://doi.org/10.20944/preprints202405.0849.v1
Nikpay, M. Multiomics Data Analyses Identified CpG Sites and Genes That Mediate the Impact of Exposure to Environmental Chemicals on Cardiometabolic Traits. Preprints2024, 2024050849. https://doi.org/10.20944/preprints202405.0849.v1
APA Style
Nikpay, M. (2024). Multiomics Data Analyses Identified CpG Sites and Genes That Mediate the Impact of Exposure to Environmental Chemicals on Cardiometabolic Traits. Preprints. https://doi.org/10.20944/preprints202405.0849.v1
Chicago/Turabian Style
Nikpay, M. 2024 "Multiomics Data Analyses Identified CpG Sites and Genes That Mediate the Impact of Exposure to Environmental Chemicals on Cardiometabolic Traits" Preprints. https://doi.org/10.20944/preprints202405.0849.v1
Abstract
Understanding the molecular mechanism whereby an environmental chemical causes a disease is important for downstream purposes. In this study, an analytical workflow was designed to combine several publicly available datasets in order to identify CpG sites and genes that mediate the impact of exposure to environmental chemicals on cardiometabolic traits. Organophosphate and prenatal lead exposure were previously reported to change methylation level at the cg23627948 site. I found as cg23627948 site becomes methylated, the expression of GNA12 gene decreases and this leads to higher body fat percentage. Prenatal perfluorooctane sulfonate expo-sure was reported to increase the methylation level at cg21153102 site. The outcome of analyses revealed higher methylation at this site contributes to higher diastolic blood by changing the expression of CHP1 and GCHFR genes. Furthermore, HKR1 mediates the impact of B12 supple-mentation-cg05280698 hypermethylation on higher kidney function; while, CTDNEP1 mediates the impact of air pollution-cg03186999 hypomethylation on higher systolic blood pressure. This study reports CpG sites and genes that mediate the impact of environmental chemicals on cardiometabolic traits and describes a framework to investigate the underlying molecular paths using publicly available data.
Keywords
Environmental chemicals; cardiometabolic traits, DNA methylation; epigenome; Mendelian randomization; multiomics
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
