Version 1
: Received: 29 April 2024 / Approved: 30 April 2024 / Online: 30 April 2024 (11:55:59 CEST)
How to cite:
Billi, M.; De Marinis, E.; Gentile, M.; Nervi, C.; Grignani, F. Nuclear miRNAs: gene regulation activities. Preprints2024, 2024042002. https://doi.org/10.20944/preprints202404.2002.v1
Billi, M.; De Marinis, E.; Gentile, M.; Nervi, C.; Grignani, F. Nuclear miRNAs: gene regulation activities. Preprints 2024, 2024042002. https://doi.org/10.20944/preprints202404.2002.v1
Billi, M.; De Marinis, E.; Gentile, M.; Nervi, C.; Grignani, F. Nuclear miRNAs: gene regulation activities. Preprints2024, 2024042002. https://doi.org/10.20944/preprints202404.2002.v1
APA Style
Billi, M., De Marinis, E., Gentile, M., Nervi, C., & Grignani, F. (2024). Nuclear miRNAs: gene regulation activities. Preprints. https://doi.org/10.20944/preprints202404.2002.v1
Chicago/Turabian Style
Billi, M., Clara Nervi and Francesco Grignani. 2024 "Nuclear miRNAs: gene regulation activities" Preprints. https://doi.org/10.20944/preprints202404.2002.v1
Abstract
MicroRNAs are small non-coding RNAs, which contribute to the regulation of many physiolog-ical and pathological processes. Conventionally, miRNAs perform their activity in the cyto-plasm, where they regulate gene expression by interacting in a sequence-specific manner with mature messenger RNAs. Recent studies point to the presence of mature miRNAs in the nucleus. This review summarizes current findings regarding the molecular activities of nuclear miRNAs. These molecules can regulate gene expression at the transcriptional level by directly binding DNA on the promoter or the enhancer of regulated genes. MiRNAs recruit to these regions dif-ferent protein complexes, resulting both in activation or repression of transcription, through a number of molecular mechanisms. Haematopoiesis is presented as a paradigmatic biological process whereby nuclear miRNAs possess a relevant regulatory role. Nuclear miRNAs may af-fect gene expression also acting on nuclear mRNA processing and on the biogenesis of miRNA themselves by regulating pri-miRNA maturation. Overall, nuclear miRNAs are biologically ac-tive molecules that can be critical for the fine tuning of gene expression and deserve further studies in a number of physiological and pathological conditions
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
