Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Cardiovascular Risk Profile in Ménière’s Disease and Posterior Circulation Infarction: A Comparative Study

Francisco Alves de Sousa
* ORCID logo ,
João Tarrio
,
Rita Rodrigues
,
Clara Serdoura Alves
,
Mariline Santos
,
Ana Nóbrega Pinto
,
Luís Meireles
,
Ângela Reis Rego
Version 1 : Received: 26 April 2024 / Approved: 28 April 2024 / Online: 28 April 2024 (05:37:06 CEST)

How to cite: Sousa, F.A.D.; Tarrio, J.; Rodrigues, R.; Serdoura Alves, C.; Santos, M.; Nóbrega Pinto, A.; Meireles, L.; Reis Rego, Â. Cardiovascular Risk Profile in Ménière’s Disease and Posterior Circulation Infarction: A Comparative Study. Preprints 2024, 2024041820. https://doi.org/10.20944/preprints202404.1820.v1 Sousa, F.A.D.; Tarrio, J.; Rodrigues, R.; Serdoura Alves, C.; Santos, M.; Nóbrega Pinto, A.; Meireles, L.; Reis Rego, Â. Cardiovascular Risk Profile in Ménière’s Disease and Posterior Circulation Infarction: A Comparative Study. Preprints 2024, 2024041820. https://doi.org/10.20944/preprints202404.1820.v1

Abstract

Ménière's disease (MD) has an unclear cause. The microvascular dysregulation of the inner ear has been increasingly pointed as a potential contributor. This study investigates the prevalence of cardiovascular risk factors (CVRFs) in MD patients compared to those with posterior circulation cerebral infarction (POCI). CVRFs like hypertension, diabetes, dyslipidemia, obesity, coronary heart disease, and smoking were assessed in both MD and POCI patients. Brain MRI identified POCI etiology as "small vessel occlusion" (SVO) or "other etiology" (OE). The study included 64 MD and 84 POCI patients. Compared to MD, POCI OE showed a higher prevalence of CVRFs across various age groups, including hypertension, diabetes, dyslipidemia, and smoking. Notably, the odds of having POCI OE were significantly higher for individuals with hypertension and smoking. On the other hand, POCI SVO showed similar prevalence of CVRFs compared to MD. This study reveals no significant difference in CVRF prevalence between MD and smaller vessel POCI. However, a clear distinction emerges when comparing MD to POCI with involvement of larger blood vessels. Further research is needed to confirm these findings and explore potential shared risk factors between POCI (SVO) and MD.

Keywords

Ménière´s disease; stroke; vertebrobasilar; cardiovascular; risk factors; microcirculation; inner ear; posterior circulation; POCI; cerebral

Subject

Medicine and Pharmacology, Otolaryngology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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