Encapsulated Bacteria with a Light-Repressed Deadman Switch for Liver Gene Delivery

Michael Renteln

doi:10.20944/preprints202404.1631.v1

Preprint Hypothesis Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 24 April 2024 / Approved: 24 April 2024 / Online: 25 April 2024 (09:00:58 CEST)
Version 2 : Received: 26 April 2024 / Approved: 26 April 2024 / Online: 26 April 2024 (14:49:58 CEST)

Adeno-associated viruses (AAVs) have been used for liver gene therapy. Hemgenix and Roctavian are AAV-based treatments for hemophilia B and A, respectively. They cost $3 million and $2.8 million per dose, respectively. While AAV vectors may eventually be cheaper to mass produce, a bacteria-based DNA delivery system might be much cheaper for patients. Also, “bactofection” would allow for the delivery of much larger DNA packages. Such a bacterial system may now be possible, and a prototype for the liver could possibly be developed immediately.

encapsulation; adeno-associated virus (AAV); light-activated allosteric protein switch; Deadman switch; T4 bacteriophage gene delivery vector; facultative intracellular bacteria

Biology and Life Sciences, Biology and Biotechnology

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Encapsulated Bacteria with a Light-Repressed Deadman Switch for Liver Gene Delivery

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