Version 1
: Received: 21 April 2024 / Approved: 22 April 2024 / Online: 22 April 2024 (10:29:02 CEST)
How to cite:
Hoyos, A.B.; Salas, A.; Osiovich, H.; Fajardo, C.A.; Baez, M.; Monterrosa, L.; Villegas Alvarez, C.; Aguinaga, F.; Martinini, M.I. Use and Abuse of Antibiotics in Latin American Neonatal Units in the EpicLatino Database Eight Years of Experience. Preprints2024, 2024041381. https://doi.org/10.20944/preprints202404.1381.v1
Hoyos, A.B.; Salas, A.; Osiovich, H.; Fajardo, C.A.; Baez, M.; Monterrosa, L.; Villegas Alvarez, C.; Aguinaga, F.; Martinini, M.I. Use and Abuse of Antibiotics in Latin American Neonatal Units in the EpicLatino Database Eight Years of Experience. Preprints 2024, 2024041381. https://doi.org/10.20944/preprints202404.1381.v1
Hoyos, A.B.; Salas, A.; Osiovich, H.; Fajardo, C.A.; Baez, M.; Monterrosa, L.; Villegas Alvarez, C.; Aguinaga, F.; Martinini, M.I. Use and Abuse of Antibiotics in Latin American Neonatal Units in the EpicLatino Database Eight Years of Experience. Preprints2024, 2024041381. https://doi.org/10.20944/preprints202404.1381.v1
APA Style
Hoyos, A.B., Salas, A., Osiovich, H., Fajardo, C.A., Baez, M., Monterrosa, L., Villegas Alvarez, C., Aguinaga, F., & Martinini, M.I. (2024). Use and Abuse of Antibiotics in Latin American Neonatal Units in the EpicLatino Database Eight Years of Experience. Preprints. https://doi.org/10.20944/preprints202404.1381.v1
Chicago/Turabian Style
Hoyos, A.B., Fernando Aguinaga and Maria Ines Martinini. 2024 "Use and Abuse of Antibiotics in Latin American Neonatal Units in the EpicLatino Database Eight Years of Experience" Preprints. https://doi.org/10.20944/preprints202404.1381.v1
Abstract
The use of antibiotics in neonatal units worldwide varies significantly. We included data from 2015-2022 from the EpicLatino database, which comprises a network of 32 units in Latin America and the Caribbean with gestational age at birth (GA) of ≤ 32 weeks. A questionnaire was sent to the EpicLatino units, to correlate practice with outcomes. Negative binomial regression with standard errors and confidence intervals computed for incidence-rate ratios (IRRs) was used for comparative statistics on antibiotic days per 1000 patient-days between units. All units that responded had 1-6 differences with the reference unit (Unit 2) with the best results, but there was no clear association with the IRR. Each EpicLatino unit should review its statistics to explore possibilities for reducing antibiotic usage.
Keywords
Antibiotic use in neonatal units; preterm infants; EpicLatino database
Subject
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
