Version 1
: Received: 20 April 2024 / Approved: 21 April 2024 / Online: 22 April 2024 (16:30:32 CEST)
How to cite:
Yuksel, B.; Albayrak, T. Prognostic Value of Fibrosis 4 (FIB-4) Index in Sepsis Patients. Preprints2024, 2024041373. https://doi.org/10.20944/preprints202404.1373.v1
Yuksel, B.; Albayrak, T. Prognostic Value of Fibrosis 4 (FIB-4) Index in Sepsis Patients. Preprints 2024, 2024041373. https://doi.org/10.20944/preprints202404.1373.v1
Yuksel, B.; Albayrak, T. Prognostic Value of Fibrosis 4 (FIB-4) Index in Sepsis Patients. Preprints2024, 2024041373. https://doi.org/10.20944/preprints202404.1373.v1
APA Style
Yuksel, B., & Albayrak, T. (2024). Prognostic Value of Fibrosis 4 (FIB-4) Index in Sepsis Patients. Preprints. https://doi.org/10.20944/preprints202404.1373.v1
Chicago/Turabian Style
Yuksel, B. and Tuna Albayrak. 2024 "Prognostic Value of Fibrosis 4 (FIB-4) Index in Sepsis Patients" Preprints. https://doi.org/10.20944/preprints202404.1373.v1
Abstract
.Bacground: Sepsis remains a major health challenge worldwide, characterized by a dysre-gulated host response to infection, leading to high mortality and morbidity in intensive care units (ICUs). The Fibrosis 4 (FIB-4) index, originally developed to assess liver fibrosis in hepatitis C patients, has recently been explored for its potential prognostic value in sepsis patients. Method: This study retrospectively analyzed 309 sepsis patients admitted to the Internal Me-dicine and Anaesthesia ICUs between December 12, 2021, and December 15, 2023, to inves-tigate the relationship between FIB-4 levels, Acute Physiology and Chronic Health Evaluation (APACHE), and Sequential Organ Failure Assessment (SOFA) and clinical outcomes. Results: The study found that higher FIB-4 measurements were statistically significantly asso-ciated with increased 28-day mortality, with a cut-off value of 4.9 providing a sensitivity of 54.92% and specificity of 74.25%. Logistic regression analysis indicated that elevated Conclusion:FIB-4 levels were a significant predictor of early mortality, suggesting that the FIB-4 index could serve as a valuable prognostic tool in assessing the severity and prognosis of sepsis patients.
Keywords
Sepsis prognosis; FIB-4 index; Intensive care units (ICUs); Early mortality prediction; Risk stratification
Subject
Medicine and Pharmacology, Anesthesiology and Pain Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
