Anti‐Candida Phytochemicals and Isolated Compounds in Anacardiaceae Family—An Updated Review and In‐Silico Analysis

Aluisio Silva Oliveira; Josivan Regis Farias; Danielle Cristine Gomes Franco; Arthur Andre Castro da Costa; Pamela Gomes Santos; Mayara Cristina Pinto Silva; Flavia Raquel Fernandes Nascimento; Rosane Nassar Meireles Guerra

doi:10.20944/preprints202404.1065.v1

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preprints.org > biology and life sciences > immunology and microbiology > doi: 10.20944/preprints202404.1065.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Anti‐Candida Phytochemicals and Isolated Compounds in Anacardiaceae Family—An Updated Review and In‐Silico Analysis

Aluisio Silva Oliveira

Josivan Regis Farias

Danielle Cristine Gomes Franco

Arthur Andre Castro da Costa

Pamela Gomes Santos

Mayara Cristina Pinto Silva

Flavia Raquel Fernandes Nascimento

Rosane Nassar Meireles Guerra

Version 1 : Received: 15 April 2024 / Approved: 16 April 2024 / Online: 16 April 2024 (17:13:39 CEST)

How to cite: Oliveira, A.S.; Farias, J.R.; Franco, D.C.G.; Costa, A.A.C.D.; Santos, P.G.; Silva, M.C.P.; Nascimento, F.R.F.; Guerra, R.N.M. Anti‐Candida Phytochemicals and Isolated Compounds in Anacardiaceae Family—An Updated Review and In‐Silico Analysis. Preprints 2024, 2024041065. https://doi.org/10.20944/preprints202404.1065.v1 Oliveira, A.S.; Farias, J.R.; Franco, D.C.G.; Costa, A.A.C.D.; Santos, P.G.; Silva, M.C.P.; Nascimento, F.R.F.; Guerra, R.N.M. Anti‐Candida Phytochemicals and Isolated Compounds in Anacardiaceae Family—An Updated Review and In‐Silico Analysis. Preprints 2024, 2024041065. https://doi.org/10.20944/preprints202404.1065.v1

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MDPI and ACS Style

Oliveira, A.S.; Farias, J.R.; Franco, D.C.G.; Costa, A.A.C.D.; Santos, P.G.; Silva, M.C.P.; Nascimento, F.R.F.; Guerra, R.N.M. Anti‐Candida Phytochemicals and Isolated Compounds in Anacardiaceae Family—An Updated Review and In‐Silico Analysis. Preprints 2024, 2024041065. https://doi.org/10.20944/preprints202404.1065.v1

APA Style

Oliveira, A.S., Farias, J.R., Franco, D.C.G., Costa, A.A.C.D., Santos, P.G., Silva, M.C.P., Nascimento, F.R.F., & Guerra, R.N.M. (2024). Anti‐Candida Phytochemicals and Isolated Compounds in Anacardiaceae Family—An Updated Review and In‐Silico Analysis. Preprints. https://doi.org/10.20944/preprints202404.1065.v1

Chicago/Turabian Style

Oliveira, A.S., Flavia Raquel Fernandes Nascimento and Rosane Nassar Meireles Guerra. 2024 "Anti‐Candida Phytochemicals and Isolated Compounds in Anacardiaceae Family—An Updated Review and In‐Silico Analysis" Preprints. https://doi.org/10.20944/preprints202404.1065.v1

Abstract

Fungal infections caused by Candida spp. are responsible for high hospital morbidity and mortality rates. Therefore, there is a continuous search for new antifungal medicines, particularly ones with anti-Candida activity. This review analyzed articles published between 2002 and 2023 considering the anti-Candida activity of chemical compounds identified or isolated in plants of the Anacardiaceae family. In addition, the in-silico prediction of the isolated compounds described was performed. The analysis of 35 studies showed that extracts, essential oils, and compounds from the anti-Candida activity were frequently determined in vitro using the minimum inhibitory concentration (MIC). The most commonly tested species were Candida albicans, C. tropicalis, C. parapsilosis, C. glabrata, C. krusei, and C. guilliermondii, respectively. Essential oils were the most used form (37% of the studies). The isolated compounds with antifungal effects include cardanol, estragole, trans-anethole, β-caryophyllene, myrcene, catechin-3-o-rhamnoside, β-sitosterol-3-O-glucoside, 24Z-isomasticadienolic acid, oleanolic acid, and oleanolic aldehyde. The in-silico evaluation of those isolated compounds revealed the compounds' drug-likeness and possible antifungal activity. However, some of them showed high toxicity. In conclusion, compounds from the Anacardiaceae family show promise for developing new therapeutic antifungal drugs, especially in combination with conventional antifungals.

Keywords

Anacardiaceae; gallic acid; ADMET; drug-likeness; Candida albicans; antifungal

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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