Genetics and Molecular Mechanisms of Idiopathic Dilated Cardiomyopathy, a Possible Guide to Individualized Management

Diana-Aurora Arnautu; Octavian-Marius Cretu; Daniel Florin Lighezan; Minodora Andor; Ioana Citu; Dragoș Cozma; Brenda-Cristiana Bernad; Adrian-Pavel Trifa; Diana Lighezan; Elena-Silvia Bernad; Dragos Catalin Jianu; Cristian Oancea; Ioan-Radu Lala; Sergiu-Florin Arnautu; Mirela-Cleopatra Tomescu

doi:10.20944/preprints202404.1054.v1

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preprints.org > biology and life sciences > life sciences > doi: 10.20944/preprints202404.1054.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Genetics and Molecular Mechanisms of Idiopathic Dilated Cardiomyopathy, a Possible Guide to Individualized Management

Diana-Aurora Arnautu

Octavian-Marius Cretu

Daniel Florin Lighezan

Minodora Andor

Ioana Citu

Dragoș Cozma

Brenda-Cristiana Bernad

Sergiu-Florin Arnautu

^* ,

Mirela-Cleopatra Tomescu

Version 1 : Received: 16 April 2024 / Approved: 16 April 2024 / Online: 16 April 2024 (15:53:28 CEST)

How to cite: Arnautu, D.; Cretu, O.; Lighezan, D.F.; Andor, M.; Citu, I.; Cozma, D.; Bernad, B.; Trifa, A.; Lighezan, D.; Bernad, E.; Jianu, D.C.; Oancea, C.; Lala, I.; Arnautu, S.; Tomescu, M. Genetics and Molecular Mechanisms of Idiopathic Dilated Cardiomyopathy, a Possible Guide to Individualized Management. Preprints 2024, 2024041054. https://doi.org/10.20944/preprints202404.1054.v1 Arnautu, D.; Cretu, O.; Lighezan, D.F.; Andor, M.; Citu, I.; Cozma, D.; Bernad, B.; Trifa, A.; Lighezan, D.; Bernad, E.; Jianu, D.C.; Oancea, C.; Lala, I.; Arnautu, S.; Tomescu, M. Genetics and Molecular Mechanisms of Idiopathic Dilated Cardiomyopathy, a Possible Guide to Individualized Management. Preprints 2024, 2024041054. https://doi.org/10.20944/preprints202404.1054.v1

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MDPI and ACS Style

Arnautu, D.; Cretu, O.; Lighezan, D.F.; Andor, M.; Citu, I.; Cozma, D.; Bernad, B.; Trifa, A.; Lighezan, D.; Bernad, E.; Jianu, D.C.; Oancea, C.; Lala, I.; Arnautu, S.; Tomescu, M. Genetics and Molecular Mechanisms of Idiopathic Dilated Cardiomyopathy, a Possible Guide to Individualized Management. Preprints 2024, 2024041054. https://doi.org/10.20944/preprints202404.1054.v1

APA Style

Arnautu, D., Cretu, O., Lighezan, D.F., Andor, M., Citu, I., Cozma, D., Bernad, B., Trifa, A., Lighezan, D., Bernad, E., Jianu, D.C., Oancea, C., Lala, I., Arnautu, S., & Tomescu, M. (2024). Genetics and Molecular Mechanisms of Idiopathic Dilated Cardiomyopathy, a Possible Guide to Individualized Management. Preprints. https://doi.org/10.20944/preprints202404.1054.v1

Chicago/Turabian Style

Arnautu, D., Sergiu-Florin Arnautu and Mirela-Cleopatra Tomescu. 2024 "Genetics and Molecular Mechanisms of Idiopathic Dilated Cardiomyopathy, a Possible Guide to Individualized Management" Preprints. https://doi.org/10.20944/preprints202404.1054.v1

Abstract

Considering the worldwide impact of heart failure, it is crucial to develop approaches that can help us comprehend its root cause and make accurate predictions about its outcome. This is essential for lowering the suffering and death rates connected with this widespread illness. Cardiomyopathies frequently result from genetic factors, and the study of heart failure genetics is advancing quickly. Dilated cardiomyopathy (DCM) is the most prevalent kind of cardiomyopathy, encompassing both hereditary and nongenetic abnormalities. It is distinguished by the enlargement of the left ventricle or both ventricles, accompanied by reduced contractility. The discovery of the molecular origins and subsequent awareness of the molecular mechanism is broadening our knowledge of DCM development. Additionally, it emphasizes the complicated nature of DCM and the necessity to formulate several different strategies to address the diverse underlying factors contributing to this disease. Genetic variations that can be transmitted from one generation to another can be a significant contributor to causing family or isolated DCM. Genetic variation also plays a significant role in determining susceptibility for acquired triggers for DCM. The genetic causes of DCM can have a diverse range of phenotypic expressions. It is crucial to select the most probable patients to have advantages from genetic testing. The purpose of this research is to emphasize the significance of identifying genetic DCM, the crucial relationships between genotype and phenotype, and the usefulness of genetic testing in the therapeutic care of both those affected and their relatives. This approach is expected to gain importance once treatment is guided by genotype-specific advice and disease-modifying medications.

Keywords

dilated cardiomyopathy; genetics; heart failure; genotype - specific therapy

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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