Version 1
: Received: 25 March 2024 / Approved: 26 March 2024 / Online: 27 March 2024 (15:01:31 CET)
How to cite:
Buchynskyi, M.; Oksenych, V.; Kamyshna, I.; Budarna, O.; Kamyshnyi, O. Genomic Insight into the COVID-19 Severity in MAFLD Patients: A Single-Center Prospective Cohort Study. Preprints2024, 2024031634. https://doi.org/10.20944/preprints202403.1634.v1
Buchynskyi, M.; Oksenych, V.; Kamyshna, I.; Budarna, O.; Kamyshnyi, O. Genomic Insight into the COVID-19 Severity in MAFLD Patients: A Single-Center Prospective Cohort Study. Preprints 2024, 2024031634. https://doi.org/10.20944/preprints202403.1634.v1
Buchynskyi, M.; Oksenych, V.; Kamyshna, I.; Budarna, O.; Kamyshnyi, O. Genomic Insight into the COVID-19 Severity in MAFLD Patients: A Single-Center Prospective Cohort Study. Preprints2024, 2024031634. https://doi.org/10.20944/preprints202403.1634.v1
APA Style
Buchynskyi, M., Oksenych, V., Kamyshna, I., Budarna, O., & Kamyshnyi, O. (2024). Genomic Insight into the COVID-19 Severity in MAFLD Patients: A Single-Center Prospective Cohort Study. Preprints. https://doi.org/10.20944/preprints202403.1634.v1
Chicago/Turabian Style
Buchynskyi, M., Olena Budarna and Oleksandr Kamyshnyi. 2024 "Genomic Insight into the COVID-19 Severity in MAFLD Patients: A Single-Center Prospective Cohort Study" Preprints. https://doi.org/10.20944/preprints202403.1634.v1
Abstract
This study investigated the influence of single nucleotide polymorphisms (SNPs) in genes asso-ciated with the interferon pathway (IFNAR2 rs2236757), antiviral response (OAS1 rs10774671, OAS3 rs10735079), and viral entry (ACE2 rs2074192) on COVID-19 severity and their association with non-alcoholic fatty liver disease (MAFLD). We did not observe a significant association between the investigated SNPs and COVID-19 severity. While the IFNAR2 rs2236757 A allele correlated with higher creatinine levels upon admission and the G allele with lower band neu-trophils upon discharge, these findings require further investigation. The distribution of OAS gene polymorphisms (rs10774671, rs10735079 did not differ between MAFLD and non-MAFLD patients. Our study population's distribution of ACE2 rs2074192 genotypes and alleles differed from the European reference population. Overall, our findings suggest that these specific SNPs may not be major contributors to COVID-19 severity in our patient population, highlighting the potential role of other genetic factors and environmental influences.
Medicine and Pharmacology, Epidemiology and Infectious Diseases
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
