A Randomized Comparative Clinical Trial to Assess the Efficacy of Polyherbal Metabolite Compounds in the Management of Type 2 Diabetes Mellitus

Nandakumar Kadanangode Narayanaswamy; Prasanth Subramanian; Mohanraj Nehru; Bhuvaneshwaran Mothishwaran; Rajappan Chandra Satish Kumar; Venkataraman Prabhu

doi:10.20944/preprints202403.1474.v1

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preprints.org > medicine and pharmacology > medicine and pharmacology > doi: 10.20944/preprints202403.1474.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Randomized Comparative Clinical Trial to Assess the Efficacy of Polyherbal Metabolite Compounds in the Management of Type 2 Diabetes Mellitus

Nandakumar Kadanangode Narayanaswamy

Prasanth Subramanian

Mohanraj Nehru

Bhuvaneshwaran Mothishwaran

Rajappan Chandra Satish Kumar

Venkataraman Prabhu

Version 1 : Received: 24 March 2024 / Approved: 25 March 2024 / Online: 25 March 2024 (11:22:33 CET)

How to cite: Kadanangode Narayanaswamy, N.; Subramanian, P.; Nehru, M.; Mothishwaran, B.; Kumar, R.C.S.; Prabhu, V. A Randomized Comparative Clinical Trial to Assess the Efficacy of Polyherbal Metabolite Compounds in the Management of Type 2 Diabetes Mellitus. Preprints 2024, 2024031474. https://doi.org/10.20944/preprints202403.1474.v1 Kadanangode Narayanaswamy, N.; Subramanian, P.; Nehru, M.; Mothishwaran, B.; Kumar, R.C.S.; Prabhu, V. A Randomized Comparative Clinical Trial to Assess the Efficacy of Polyherbal Metabolite Compounds in the Management of Type 2 Diabetes Mellitus. Preprints 2024, 2024031474. https://doi.org/10.20944/preprints202403.1474.v1

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MDPI and ACS Style

Kadanangode Narayanaswamy, N.; Subramanian, P.; Nehru, M.; Mothishwaran, B.; Kumar, R.C.S.; Prabhu, V. A Randomized Comparative Clinical Trial to Assess the Efficacy of Polyherbal Metabolite Compounds in the Management of Type 2 Diabetes Mellitus. Preprints 2024, 2024031474. https://doi.org/10.20944/preprints202403.1474.v1

APA Style

Kadanangode Narayanaswamy, N., Subramanian, P., Nehru, M., Mothishwaran, B., Kumar, R.C.S., & Prabhu, V. (2024). A Randomized Comparative Clinical Trial to Assess the Efficacy of Polyherbal Metabolite Compounds in the Management of Type 2 Diabetes Mellitus. Preprints. https://doi.org/10.20944/preprints202403.1474.v1

Chicago/Turabian Style

Kadanangode Narayanaswamy, N., Rajappan Chandra Satish Kumar and Venkataraman Prabhu. 2024 "A Randomized Comparative Clinical Trial to Assess the Efficacy of Polyherbal Metabolite Compounds in the Management of Type 2 Diabetes Mellitus" Preprints. https://doi.org/10.20944/preprints202403.1474.v1

Abstract

Background and Objectives: In this current state, Type 2 Diabetes Mellitus (T2DM) is more prevalent in the population, and metformin is used as a first-line medication for treating it. There was up surge in the utilization of alternative therapies in the management of diabetes. Especially in diabetes, Herbal medicines are considered safe and reliable by majority of the population. Aim: The purpose of this research is aimed to estimate the safety and efficacy of Polyherbal Metabolite Compounds (PHMC) capsules in adults with T2DM. Materials and Methods: In this study, 60 T2DM patients aged 18-60 years were randomly assigned to Groups A (30) receiving Metformin 500 mg twice a day after food and Group B (30) receiving PHMC capsule 500 mg twice a day after food in a prospective, randomized and open-label clinical study. The in-silico simulation study was performed to selected plants major compounds on target protein Insulin-like Growth Factor-1 (1K3A). Result: The PHMC is found to be safe and effective in the management of T2DM. The FBS, PPBS and HbA1c were significantly lowered (p

Keywords

Diabetes; PHMC; Cardiovascular complications; Insulin resistance; Insulin sensitivity.

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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