Moon, K.; Choi, G.; Jung, S.; Kim, H.; Park, J.; Kwon, Y.M.; Cho, E.; Shin, M.Y.; Yu, J.; Choi, J.A.; Baek, Y.; Park, S. Influenza Virus-Based Antiviral Strategy: A Broad-Spectrum Potential of a Marine Bacterium Targeting Future Pandemics. Preprints2024, 2024030554. https://doi.org/10.20944/preprints202403.0554.v1
APA Style
Moon, K., Choi, G., Jung, S., Kim, H., Park, J., Kwon, Y.M., Cho, E., Shin, M.Y., Yu, J., Choi, J.A., Baek, Y., & Park, S. (2024). Influenza Virus-Based Antiviral Strategy: A Broad-Spectrum Potential of a Marine Bacterium Targeting Future Pandemics. Preprints. https://doi.org/10.20944/preprints202403.0554.v1
Chicago/Turabian Style
Moon, K., Yeong-Bin Baek and Sang-Ik Park. 2024 "Influenza Virus-Based Antiviral Strategy: A Broad-Spectrum Potential of a Marine Bacterium Targeting Future Pandemics" Preprints. https://doi.org/10.20944/preprints202403.0554.v1
Abstract
The influenza virus has been the primary cause of the pandemic, posing a constant threat to human society. Due to its genetic evolution and continuous outbreak, antiviral research currently focuses on exploring a novel lead agent. A comprehensive antiviral screening discovered a marine bacterium whose extract exerted excellent efficacy against influenza viruses. Parerythrobacter sp. M20A3S10, a novel strain under the family Erythrobacteraceae, could produce carotenoids exhibiting antiviral and anticancer activity by enhancing the cellular immune system. Post-treatment of M20A3S10 extract showed outstanding therapeutic indexes: against influenza virus A/PR8 (H1N1) [selectivity index (SI) = 24.0], A/Wisconsin/15/2009 (H3N2) (SI = 30.1) and B/Florida/78/2015 (SI = 38.2). Comparably, the effectiveness was demonstrated against Zika virus (ZIKV) and dengue virus type 2 (DENV2) with an SI of 22.5 and 24.1, respectively, namely broad-spectrum activity. Of note, the antiviral responses resulted from the common replication mechanism between IAV, ZIKV, and DENV2. The stimulation of apoptosis-mediated cellular immunity prevented the viral release and protected the host, suggesting that switching from necroptosis to apoptosis is a novel antiviral target. Although the specific compound affecting the antiviral activity was not identified, its promising efficacy with broad activity will contribute to developing a strategy for preventing future pandemics.
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