PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Prevalence of Diabetes Mellitus and Differences in Clinical Characteristics in A Population of Patients Affected by Severe Osteoporosis and Fragility Fractures
Version 1
: Received: 5 February 2024 / Approved: 6 February 2024 / Online: 6 February 2024 (13:36:48 CET)
How to cite:
Nardone, I.; Antonelli, R.; Zaccaria, S.; Wolde Sellasie, S.; Falcone, S.; Pecchioli, C.; Giurato, L.; Uccioli, L. Prevalence of Diabetes Mellitus and Differences in Clinical Characteristics in A Population of Patients Affected by Severe Osteoporosis and Fragility Fractures. Preprints2024, 2024020349. https://doi.org/10.20944/preprints202402.0349.v1
Nardone, I.; Antonelli, R.; Zaccaria, S.; Wolde Sellasie, S.; Falcone, S.; Pecchioli, C.; Giurato, L.; Uccioli, L. Prevalence of Diabetes Mellitus and Differences in Clinical Characteristics in A Population of Patients Affected by Severe Osteoporosis and Fragility Fractures. Preprints 2024, 2024020349. https://doi.org/10.20944/preprints202402.0349.v1
Nardone, I.; Antonelli, R.; Zaccaria, S.; Wolde Sellasie, S.; Falcone, S.; Pecchioli, C.; Giurato, L.; Uccioli, L. Prevalence of Diabetes Mellitus and Differences in Clinical Characteristics in A Population of Patients Affected by Severe Osteoporosis and Fragility Fractures. Preprints2024, 2024020349. https://doi.org/10.20944/preprints202402.0349.v1
APA Style
Nardone, I., Antonelli, R., Zaccaria, S., Wolde Sellasie, S., Falcone, S., Pecchioli, C., Giurato, L., & Uccioli, L. (2024). Prevalence of Diabetes Mellitus and Differences in Clinical Characteristics in A Population of Patients Affected by Severe Osteoporosis and Fragility Fractures. Preprints. https://doi.org/10.20944/preprints202402.0349.v1
Chicago/Turabian Style
Nardone, I., Laura Giurato and Luigi Uccioli. 2024 "Prevalence of Diabetes Mellitus and Differences in Clinical Characteristics in A Population of Patients Affected by Severe Osteoporosis and Fragility Fractures" Preprints. https://doi.org/10.20944/preprints202402.0349.v1
Abstract
Background: Diabetes mellitus (DM) and osteoporosis are two of the most widespread metabolic disease in the world. The aim of this study is to investigate the prevalence of DM among patients affected by osteoporosis and fragility fractures, and to search differences in clinical features. Methods: 713 patients belonging to CTO Bone Unit because of osteoporosis and fragility fractures were divided into two groups, according to the diagnosis of DM. The clinical and bone characteristics of patients were compared. Results: Prevalence of DM was 10.8%. When compared to patients without DM, the median age at the time of first fracture was similar (72 years ± 14 IQR vs 71 years ± 12 IQR); prevalence of combination of vertebral and hip fractures was higher (p=0.039), as well as prevalence of males, although not significantly (p=0.051). Bone mineral density (BMD) at all sites was higher in DM group; Trabecular Bone Score (TBS), instead, was significantly lower (p<0.001). Conclusions: Patients with fragility fractures and DM more frequently show combination of major fractures with higher BMD levels. In these patients, TBS could be a better indicator of bone health than BMD and therefore should be used as a diagnostic tool in clinical practice.
Keywords
Osteoporosis; diabetes mellitus; fragility fractures; Bone Mineral Density (BMD); Trabecular Bone Score (TBS); bone fragility
Subject
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
