Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Long-Term Oncological Outcomes After Nerve-Sparing Robot-Assisted Radical Prostatectomy for High-Risk Localised Prostate Cancer: A Single-Center, Two-Arm, Prospective Study

Lorenzo Spirito
ORCID logo ,
Francesco Chessa
* ORCID logo ,
Anna Hagman
,
Anna Lantz
,
Giuseppe Celentano
ORCID logo ,
Rodolfo Sanchez-Salas
,
Roberto La Rocca
,
Mats Olsson
,
Olof Akre
,
Vincenzo Mirone
,
Peter Wiklund
Version 1 : Received: 19 January 2024 / Approved: 30 January 2024 / Online: 30 January 2024 (10:49:42 CET)

A peer-reviewed article of this Preprint also exists.

Spirito, L.; Chessa, F.; Hagman, A.; Lantz, A.; Celentano, G.; Sanchez-Salas, R.; La Rocca, R.; Olsson, M.; Akre, O.; Mirone, V.; Wiklund, P. Long-Term Oncological Outcomes after Nerve-Sparing Robot-Assisted Radical Prostatectomy for High-Risk Localized Prostate Cancer: A Single-Center, Two-Arm Prospective Study. Diagnostics 2024, 14, 803. Spirito, L.; Chessa, F.; Hagman, A.; Lantz, A.; Celentano, G.; Sanchez-Salas, R.; La Rocca, R.; Olsson, M.; Akre, O.; Mirone, V.; Wiklund, P. Long-Term Oncological Outcomes after Nerve-Sparing Robot-Assisted Radical Prostatectomy for High-Risk Localized Prostate Cancer: A Single-Center, Two-Arm Prospective Study. Diagnostics 2024, 14, 803.

Abstract

Nerve-sparing vs. non nerve sparing surgery (NSS vs. non-NSS) is associated with improved functional outcomes in prostatectomy patients. The aim of the present study is to compare the oncological outcomes of patients with high-risk localized prostate cancer undergoing nerve-sparing and non nerve-sparing robot-assisted radical prostatectomy (RARP). Between November 2002 and December 2018, we prospectively recorded data of patients undergoing RARP for high-risk localized prostate cancer (PCa). NSS (nerve-sparing surgery) was offered based on preoperative clinical characteristics of patients and intraoperative assessment. Patients were stratified into 2 groups according to NSS. The primary outcome was biochemical recurrence (BCR), while positive surgical margin (PSM) and cancer-specific survival (CSS) were secondary outcomes. Logistic regression was used to investigate predictive factors. A total of 779 patients were included in the study, 429 (55.1%) underwent NSS while 350 (44.9%) underwent a non-NSS. After a mean (±SD) follow-up of 192 (±14) months, 328 (42.1%) patients developed BCR, no significant difference was found between NSS and non-NSS group (156 vs. 172; p=0.09). Both univariable and multivariable analysis found that nerve-sparing approach was not a predictor of BCR (p>0.05). NSS vs. non-NSS was not associated with worse oncological outcomes in patients with high-risk PCa

Keywords

prostate cancer; robotic prostatectomy; functional outcomes

Subject

Medicine and Pharmacology, Urology and Nephrology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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