Farkas, G.; Nagy, S.; Dévay, A.; Széchenyi, A.; Pál, S. Real-Time Cone-Growth Model for Determination of Pharmaceutical Powder Flow Properties. Pharmaceutics2024, 16, 405.
Farkas, G.; Nagy, S.; Dévay, A.; Széchenyi, A.; Pál, S. Real-Time Cone-Growth Model for Determination of Pharmaceutical Powder Flow Properties. Pharmaceutics 2024, 16, 405.
Farkas, G.; Nagy, S.; Dévay, A.; Széchenyi, A.; Pál, S. Real-Time Cone-Growth Model for Determination of Pharmaceutical Powder Flow Properties. Pharmaceutics2024, 16, 405.
Farkas, G.; Nagy, S.; Dévay, A.; Széchenyi, A.; Pál, S. Real-Time Cone-Growth Model for Determination of Pharmaceutical Powder Flow Properties. Pharmaceutics 2024, 16, 405.
Abstract
The flow properties of pellets or granules are crucial for further processing the drug dosage forms. Optimal compression or filling the multiparticulate dosage forms into capsules is influenced by forces between discrete particles, which could be partially characterized by flow properties. Several techniques were developed for the examination of flowability, including static and dynamic methods applying empirical studies and the up-to-date chaos theory; however newest methods seem only to be powerful with the supplement of empirical principles. Our experiments try to refine both the technique of analysis and the methods by finding new, alternative ways. Our approach to the flowability measurements was to set up a dynamic time-dependent model which combines empirical observations and the chaos theory on a geometrical basis, thus find new aspects regarding flow properties of pellets and granules that could be relevant for drug developers.
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