Influence of Androgen Deprivation Therapy on Development of Sarcopenia in Patients with Prostate Cancer: A Systematic Review

Marta Stelmach-Mardas; Wojciech Warchoł; Aleksandra Garczyk; Emilia Warchoł; Jolanta Korczak; Maria Litwiniuk; Beata Brajer-Luftmann; Marcin Mardas

doi:10.20944/preprints202401.1559.v1

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preprints.org > medicine and pharmacology > dietetics and nutrition > doi: 10.20944/preprints202401.1559.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Influence of Androgen Deprivation Therapy on Development of Sarcopenia in Patients with Prostate Cancer: A Systematic Review

Marta Stelmach-Mardas

^* ,

Beata Brajer-Luftmann

Marcin Mardas

Version 1 : Received: 19 January 2024 / Approved: 22 January 2024 / Online: 23 January 2024 (02:33:27 CET)

A peer-reviewed article of this Preprint also exists.

Stelmach-Mardas, M.; Warchoł, W.; Garczyk, A.; Warchoł, E.; Korczak, J.; Litwiniuk, M.; Brajer-Luftmann, B.; Mardas, M. Influence of Androgen Deprivation Therapy on the Development of Sarcopenia in Patients with Prostate Cancer: A Systematic Review. Nutrients 2024, 16, 656. Stelmach-Mardas, M.; Warchoł, W.; Garczyk, A.; Warchoł, E.; Korczak, J.; Litwiniuk, M.; Brajer-Luftmann, B.; Mardas, M. Influence of Androgen Deprivation Therapy on the Development of Sarcopenia in Patients with Prostate Cancer: A Systematic Review. Nutrients 2024, 16, 656.

Abstract

The changes in body composition during androgen deprivation therapy (ADT) in patients suffer from prostate cancer (PCa) are recognized by professionals more often as key for effective treatment. The aim of this study was to investigate the impact of ADT on the sarcopenia development in PCa. The following databases were used: PubMed, Embase, Web of Science and Scopus databases. Out of 2183 studies, 7 were included in this review. The fixed-effect model was used in the meta-analysis. Significant increase in SATI: 0.32 (95%CI: 0.13-0.51) p= 0.001, de-crease in SMI: -0.38 (95% CI: -0.57 to -0.19) p < 0.0001 and SMD: -0.46 (95% CI: -0.69 to -0.24) p < 0.0001 was observed. No statistical association was visible between ADT and changes in BMI: 0.05 (95%CI: -0.18-0.28), p= 0.686 and VATI: 0.17 (95% CI: -0.02 to 0.37), p=0.074. In conclusion, the ADT significantly contributes to the body composition changes and sarcopenia development.

Keywords

androgen deprivation therapy; ADT; sarcopenia; prostate cancer; prostatic neoplasm; systematic review

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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