Version 1
: Received: 8 January 2024 / Approved: 8 January 2024 / Online: 8 January 2024 (11:27:56 CET)
How to cite:
David, A.; Lev-Ari, S. Exploring the potential impact of non-invasive modifications of the Gut Microbiome on Cancer Immunotherapy – a narrative review. Preprints2024, 2024010594. https://doi.org/10.20944/preprints202401.0594.v1
David, A.; Lev-Ari, S. Exploring the potential impact of non-invasive modifications of the Gut Microbiome on Cancer Immunotherapy – a narrative review. Preprints 2024, 2024010594. https://doi.org/10.20944/preprints202401.0594.v1
David, A.; Lev-Ari, S. Exploring the potential impact of non-invasive modifications of the Gut Microbiome on Cancer Immunotherapy – a narrative review. Preprints2024, 2024010594. https://doi.org/10.20944/preprints202401.0594.v1
APA Style
David, A., & Lev-Ari, S. (2024). Exploring the potential impact of non-invasive modifications of the Gut Microbiome on Cancer Immunotherapy – a narrative review. Preprints. https://doi.org/10.20944/preprints202401.0594.v1
Chicago/Turabian Style
David, A. and Shaked Lev-Ari. 2024 "Exploring the potential impact of non-invasive modifications of the Gut Microbiome on Cancer Immunotherapy – a narrative review" Preprints. https://doi.org/10.20944/preprints202401.0594.v1
Abstract
The following narrative review embarks on a comprehensive exploration of the pivotal role played by the gut microbiome within the Diet-Microbiota-Immunity (DMI) tripartite, aiming to enhance anti-cancer immunotherapy efficacy.
While revolutionizing cancer treatment, resistance to immunotherapy and immune-related adverse events (irAEs) remain challenges. The tumor microenvironment (TME), shaped by cancer cells, influences immunotherapy resistance. The gut microbiome, influenced by genetics, environment, diet, and interventions, emerges as a critical player in TME reshaping, thereby modulating immune responses and treatment outcomes. Dietary patterns like the Mediterranean diet, caloric restriction modifications, and specific nutritional components show promise in influencing the tumor microenvironment and gut microbiome for better treatment outcomes. Antibiotics, disrupting gut microbiota diversity, may compromise immunotherapy efficacy.
This review emphasizes the need for tailored nutritional strategies to manipulate microbial communities, enhance immune regulation, and improve immunotherapy accessibility while minimizing side effects. Ongoing studies investigate the impact of dietary interventions on cancer immunotherapy, pointing towards promising developments in personalized cancer care. This narrative review synthesizes existing knowledge and charts a course for future investigations, presenting a holistic perspective on the dynamic interplay between dietary interventions, the gut microbiome, and cancer immunotherapy within the DMI tripartite.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
