Version 1
: Received: 27 December 2023 / Approved: 28 December 2023 / Online: 29 December 2023 (11:57:17 CET)
How to cite:
Phoon, L.; Desai, D.; Gami, V. Breaking Back and Bones: A Review on Osteoporotic Vertebral Fracture. Preprints2023, 2023122223. https://doi.org/10.20944/preprints202312.2223.v1
Phoon, L.; Desai, D.; Gami, V. Breaking Back and Bones: A Review on Osteoporotic Vertebral Fracture. Preprints 2023, 2023122223. https://doi.org/10.20944/preprints202312.2223.v1
Phoon, L.; Desai, D.; Gami, V. Breaking Back and Bones: A Review on Osteoporotic Vertebral Fracture. Preprints2023, 2023122223. https://doi.org/10.20944/preprints202312.2223.v1
APA Style
Phoon, L., Desai, D., & Gami, V. (2023). Breaking Back and Bones: A Review on Osteoporotic Vertebral Fracture. Preprints. https://doi.org/10.20944/preprints202312.2223.v1
Chicago/Turabian Style
Phoon, L., Dev Desai and Vismit Gami. 2023 "Breaking Back and Bones: A Review on Osteoporotic Vertebral Fracture" Preprints. https://doi.org/10.20944/preprints202312.2223.v1
Abstract
Osteoporotic vertebral fracture is the most common fracture from osteoporosis, and are largely undiagnosed due to the mostly asymptomatic nature of the condition. It increases the risk of subsequent fractures and contributes to societal burden. Risk factors for osteoporotic fractures are found in the WHO fracture risk assessment model and used as a tool for monitoring bone health. Vertebral fractures are diagnosed from anteroposterior and lateral spine radiographs and are confirmed with an approximate loss of 20% vertebral height as compared to adjacent vertebrae. One of the most used grading for vertebral fractures is the SQ grading. Mild vertebral fractures could easily be misdiagnosed due to some peculiarities of the vertebral column. CT scan is useful for planning surgical intervention while an MRI scan can provide information about the recency of the fracture and rule out cancer-related fractures. Management depends on the severity of the fracture which could range from conservative management to surgical vertebral augmentation and decompression. Bisphosphonates are used to treat osteoporosis in acute and long-term management of fractures. Osteoimmunological therapies such as denosumab and romosozumab are new therapeutic interventions for osteoporosis while there are many other potential treatment options. Precision medicine provides an individualized treatment approach while regenerative medicine utilizes mesenchymal stem cells for fracture repair.
Medicine and Pharmacology, Orthopedics and Sports Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
