Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Reconsideration of codon-anticodon wobble pairings in translation: decoding tables

Version 1 : Received: 27 December 2023 / Approved: 27 December 2023 / Online: 27 December 2023 (09:50:04 CET)

How to cite: Wada, M. Reconsideration of codon-anticodon wobble pairings in translation: decoding tables. Preprints 2023, 2023122074. https://doi.org/10.20944/preprints202312.2074.v1 Wada, M. Reconsideration of codon-anticodon wobble pairings in translation: decoding tables. Preprints 2023, 2023122074. https://doi.org/10.20944/preprints202312.2074.v1

Abstract

The gene translation system possesses inherent complexity in distinguishing codons with degeneracy through repertoires of aminoacyl-tRNAs in the ribosome. Implementation of inosine nucleoside at the anticodon wobble-position in certain tRNAs, especially in eukaryotes, might be arisen to establish complex decoding systems. This report introduces the novel concept of “decoding tables”, which serve as concise summaries of codon-anticodon pairings provided in codon table-like format. Utilizing tRNA genome database information and a procedure based on compiled tRNA studies, the tRNA repertoire and the use of wobble pairings can be depicted for any organisms. The decoding table sheds light on the use of wobble pairings across diverse organisms.

Keywords

decoding; tRNA; wobble pairing; genetic code; inosine; translation

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

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