Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Mean Oral Cavity Organ at Risk Dose Predicts Opioid Use and Hospitalization During Radiotherapy for Patients with Head and Neck Tumors

Robert L. Foote
* ORCID logo ,
William S. Harmsen
,
Adam C. Amundson
,
Alan B. Carr
,
Mauricio E. Gamez
,
Yolanda I. Garces
,
Scott C. Lester
,
Daniel J. Ma
,
Lisa A. McGee
,
Eric J. Moore
,
Michelle A. Neben Wittich
,
Samir H. Patel
,
David M. Routman
,
Jean-Claude M. Rwigema
,
Kathryn M. Van Abel
,
Linda X. Yin
,
Olivia M. Muller
,
Satomi Shiraishi
Version 1 : Received: 11 December 2023 / Approved: 12 December 2023 / Online: 13 December 2023 (06:20:32 CET)

A peer-reviewed article of this Preprint also exists.

Foote, R.L.; Harmsen, W.S.; Amundson, A.C.; Carr, A.B.; Gamez, M.E.; Garces, Y.I.; Lester, S.C.; Ma, D.J.; McGee, L.A.; Moore, E.J.; Neben Wittich, M.A.; Patel, S.H.; Routman, D.M.; Rwigema, J.-C.M.; Van Abel, K.M.; Yin, L.X.; Muller, O.M.; Shiraishi, S. Mean Oral Cavity Organ-at-Risk Dose Predicts Opioid Use and Hospitalization during Radiotherapy for Patients with Head and Neck Tumors. Cancers 2024, 16, 349. Foote, R.L.; Harmsen, W.S.; Amundson, A.C.; Carr, A.B.; Gamez, M.E.; Garces, Y.I.; Lester, S.C.; Ma, D.J.; McGee, L.A.; Moore, E.J.; Neben Wittich, M.A.; Patel, S.H.; Routman, D.M.; Rwigema, J.-C.M.; Van Abel, K.M.; Yin, L.X.; Muller, O.M.; Shiraishi, S. Mean Oral Cavity Organ-at-Risk Dose Predicts Opioid Use and Hospitalization during Radiotherapy for Patients with Head and Neck Tumors. Cancers 2024, 16, 349.

Abstract

Background: Approximately 75% of all head and neck cancer patients are treated with radiotherapy (RT). RT to the oral cavity results in acute and late adverse events which can be severe and detrimental to a patient’s quality of life and function. The purpose of this study was to explore associations between RT dose to a defined oral cavity organ at risk (OAR) avoidance structure, provider and patient reported outcomes (PROs), opioid use, and hospitalization. Methods: This was a retrospective analysis of prospectively obtained outcomes using multivariable modeling. The study included 196 patients treated with RT involving the oral cavity for a head and neck tumor. A defined oral cavity OAR avoidance structure was used in all patients for RT treatment planning. Validated PROs were collected prospectively. Opioid use and hospitalization were abstracted electronically from medical records. Results: Multivariable modeling revealed the mean dose to the oral cavity OAR was significantly associated with opioid use (p=0.0082) and hospitalization (p=0.0356) during and within 30 days of completing RT. Conclusion: The findings of this study may be valuable in RT treatment planning for patients with tumors of the head and neck region to reduce the need for opioid use and hospitalization during treatment.

Keywords

radiotherapy; head and neck cancer; oral cavity; organ at risk; adverse events

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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