Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Secondary Sarcopenia and Spinal Cord Injury: Clinical Correlations and Health Outcomes

Anamaria Gherle
,
Carmen Delia Nistor Cseppento
* ,
Diana Carina Iovanovici
* ORCID logo ,
Iulia Ruxandra Cevei
,
Mariana Lidia Cevei
,
Danche Vasilieva
ORCID logo ,
Stefania Deac
,
Dorina Stoicanescu
Version 1 : Received: 8 December 2023 / Approved: 8 December 2023 / Online: 8 December 2023 (14:40:25 CET)

A peer-reviewed article of this Preprint also exists.

Gherle, A.; Nistor-Cseppento, C.D.; Iovanovici, D.-C.; Cevei, I.R.; Cevei, M.L.; Vasileva, D.; Deac, S.; Stoicanescu, D. Secondary Sarcopenia and Spinal Cord Injury: Clinical Associations and Health Outcomes. J. Clin. Med. 2024, 13, 885. Gherle, A.; Nistor-Cseppento, C.D.; Iovanovici, D.-C.; Cevei, I.R.; Cevei, M.L.; Vasileva, D.; Deac, S.; Stoicanescu, D. Secondary Sarcopenia and Spinal Cord Injury: Clinical Associations and Health Outcomes. J. Clin. Med. 2024, 13, 885.

Abstract

Background. Sarcopenia and spinal cord injury (SCI) often coexist, but little is known about the associations of these two pathologies. This study aimed to assess the impact of SCI on muscle and bone mass and the correlations between clinical characteristics of SCI patients and sarcopenia. Methods: 136 patients diagnosed with SCI admitted to rehabilitation hospital were included in the study. The type and severity of injury (AIS), the level of spasticity (MAS), bone mineral density and Appendicular Lean Muscle Mass (ALM) were assessed. Sarcopenia was diagnosed according to the recommended EWGSOP2 cut-off points for ALM. Results: There was a statistically significant association between the ALM value and the gender, 75% of women developing sarcopenia. Among men, 42.9% had sarcopenia. Over 55% of AIS Grades A and B cases had sarcopenia. Mean age of sarcopenic patients was 35.8 years and they had multiple comorbidities. 51.6% of the patients with osteoporosis had sarcopenia. 69.7% of MAS level 0 cases had sarcopenia, while this was diagnosed in about 40% of patients with MAS levels 1-4. Conclusions: Gender, type of injury, presence of multiple comorbidities and age were directly associated with sarcopenia, while surprisingly, spasticity level and the presence of immobilization osteoporosis were not.

Keywords

spinal cord injury; sarcopenia; immobilization osteoporosis; spasticity

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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