Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Intrauterine Growth Restriction: Improving Diagnostic Accuracy and the Role of Oxidative Stress in Neonatal and Long-Term Sequels

Eva Nüsken
ORCID logo ,
Sarah Appel
ORCID logo ,
Leon Saschin
,
Celien Kuiper-Makris
ORCID logo ,
Laura Oberholz
,
Charlotte Schömig
ORCID logo ,
Anne Tauscher
,
Jörg Dötsch
,
Angela Kribs
,
Miguel A. Alejandre Alcazar
ORCID logo ,
Kai Dietrich Nüsken
* ORCID logo
Version 1 : Received: 6 December 2023 / Approved: 7 December 2023 / Online: 7 December 2023 (07:09:49 CET)

How to cite: Nüsken, E.; Appel, S.; Saschin, L.; Kuiper-Makris, C.; Oberholz, L.; Schömig, C.; Tauscher, A.; Dötsch, J.; Kribs, A.; Alejandre Alcazar, M. A.; Nüsken, K. D. Intrauterine Growth Restriction: Improving Diagnostic Accuracy and the Role of Oxidative Stress in Neonatal and Long-Term Sequels. Preprints 2023, 2023120459. https://doi.org/10.20944/preprints202312.0459.v1 Nüsken, E.; Appel, S.; Saschin, L.; Kuiper-Makris, C.; Oberholz, L.; Schömig, C.; Tauscher, A.; Dötsch, J.; Kribs, A.; Alejandre Alcazar, M. A.; Nüsken, K. D. Intrauterine Growth Restriction: Improving Diagnostic Accuracy and the Role of Oxidative Stress in Neonatal and Long-Term Sequels. Preprints 2023, 2023120459. https://doi.org/10.20944/preprints202312.0459.v1

Abstract

Intrauterine growth restriction (IUGR) and being born small for gestational age (SGA) are two distinct conditions with different implications for child development. IUGR is associated with greater perinatal morbidity and mortality and can be identified by additional abnormalities (pathological Doppler sonography, oligohydramnios, lack of growth in the interval, estimated weight <3rd percentile). IUGR may also be present in neonates with birth weights above the 10th percentile. Recognizing fetuses being “at risk” of a higher perinatal mortality and morbidity rate in order to monitor them accordingly and deliver them in good time is still challenging. This review article summarizes approaches to increase the diagnostic accuracy of IUGR and presents current concepts of pathophysiology with a focus on oxidative stress and consecutive inflammatory and metabolic changes. Since prenatal influences affect the risk of later diseases, we also discuss the need for interdisciplinary follow-up strategies during childhood and look at future scientific challenges. It should be emphasized that prenatal and postnatal care of IUGR neonates should be regarded as a continuum.

Keywords

intrauterine growth restriction; diagnostic accuracy; acute and long-term sequels; oxidative stress; antioxidants

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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