Černý, A.; Hill, M.; Vosátková, M.; Laštůvka, Z.; Pařízek, A. Steroid Metabolome Analysis in Dichorionic Diamniotic Twin Pregnancy. Int. J. Mol. Sci.2024, 25, 1591.
Černý, A.; Hill, M.; Vosátková, M.; Laštůvka, Z.; Pařízek, A. Steroid Metabolome Analysis in Dichorionic Diamniotic Twin Pregnancy. Int. J. Mol. Sci. 2024, 25, 1591.
Černý, A.; Hill, M.; Vosátková, M.; Laštůvka, Z.; Pařízek, A. Steroid Metabolome Analysis in Dichorionic Diamniotic Twin Pregnancy. Int. J. Mol. Sci.2024, 25, 1591.
Černý, A.; Hill, M.; Vosátková, M.; Laštůvka, Z.; Pařízek, A. Steroid Metabolome Analysis in Dichorionic Diamniotic Twin Pregnancy. Int. J. Mol. Sci. 2024, 25, 1591.
Abstract
Steroid hormones have diverse roles in pregnancy; some, such as progesterone and its metabolites, help stabilise pregnancy and can very likely influence the stability of pregnancy and the onset of labour. Changes and disorders in steroidogenesis may be involved in several pregnancy pathologies, such as premature delivery, preeclampsia, and intrahepatic cholestasis. To date, only a few studies have performed steroid analysis in multiple pregnancies. However, these studies offered a limited analysis of the steroidome in children and mothers with multiple pregnancies. Our team and a team from the Department of Steroids and Proteofactors of the Institute of Endocrinology in Prague investigated multiple pregnancies regarding the biosynthesis, transport, and effects of steroids. We recruited two groups of patients: pregnant women with multiple pregnancies as the study group and singleton pregnancies as the control group. Blood samples were drawn from the participants and analysed. Information about the mother, foetus, delivery, and newborn was extracted from medical records. The data were then analysed. The gestational age of twin pregnancies during delivery ranged from 35+3 to 39+3 weeks, while it was 38+1 to 41+1 weeks for the controls. Our findings provide answers to questions regarding the steroidome in multiple pregnancies.
Medicine and Pharmacology, Obstetrics and Gynaecology
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