PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Exploring the Potential Relationship Between Oxidative Stress in Fertile Individuals and Secondary Infertility: A Comparative Analysis of Proteomic Profiles in Seminal Plasma
Version 1
: Received: 14 November 2023 / Approved: 15 November 2023 / Online: 15 November 2023 (10:05:00 CET)
How to cite:
Sawaid Kaiyal, R.; Mukherjee, S.D.; Panner Selvam, M.K.; AW, M.; Vij, S.C.; Lundy, S.D. Exploring the Potential Relationship Between Oxidative Stress in Fertile Individuals and Secondary Infertility: A Comparative Analysis of Proteomic Profiles in Seminal Plasma. Preprints2023, 2023110957. https://doi.org/10.20944/preprints202311.0957.v1
Sawaid Kaiyal, R.; Mukherjee, S.D.; Panner Selvam, M.K.; AW, M.; Vij, S.C.; Lundy, S.D. Exploring the Potential Relationship Between Oxidative Stress in Fertile Individuals and Secondary Infertility: A Comparative Analysis of Proteomic Profiles in Seminal Plasma. Preprints 2023, 2023110957. https://doi.org/10.20944/preprints202311.0957.v1
Sawaid Kaiyal, R.; Mukherjee, S.D.; Panner Selvam, M.K.; AW, M.; Vij, S.C.; Lundy, S.D. Exploring the Potential Relationship Between Oxidative Stress in Fertile Individuals and Secondary Infertility: A Comparative Analysis of Proteomic Profiles in Seminal Plasma. Preprints2023, 2023110957. https://doi.org/10.20944/preprints202311.0957.v1
APA Style
Sawaid Kaiyal, R., Mukherjee, S.D., Panner Selvam, M.K., AW, M., Vij, S.C., & Lundy, S.D. (2023). Exploring the Potential Relationship Between Oxidative Stress in Fertile Individuals and Secondary Infertility: A Comparative Analysis of Proteomic Profiles in Seminal Plasma. Preprints. https://doi.org/10.20944/preprints202311.0957.v1
Chicago/Turabian Style
Sawaid Kaiyal, R., Sarah C Vij and Scott D Lundy. 2023 "Exploring the Potential Relationship Between Oxidative Stress in Fertile Individuals and Secondary Infertility: A Comparative Analysis of Proteomic Profiles in Seminal Plasma" Preprints. https://doi.org/10.20944/preprints202311.0957.v1
Abstract
Oxidative stress is increasingly implicated in male secondary infertility, where the seminal plasma altered proteome composition plays a critical role. This study aims to explore proteomic changes in the seminal plasma of fertile individuals with oxidative stress and secondary infertility patients, hypothesizing oxidative stress as a key factor in secondary infertility. Pooled semen samples from both groups underwent quantitative proteomics analysis using advanced mass spectrometry, with subsequent bioinformatic analysis using tools like DAVID, STRING, and IPA for identifying differentially expressed proteins (DEPs). The study identified 377 DEPs in the secondary infertile group and 523 DEPs in healthy controls, revealing seven mutual pathways including acute phase response signaling and free radical scavenging. Significant alterations were noted in proteins like C3 and SERPINA3, associated with sperm function and fertility. The findings suggest that oxidative stress-induced proteomic alterations in seminal plasma are linked to secondary infertility, highlighting potential biomarkers and therapeutic targets. This research underscores the importance of understanding the interplay between oxidative stress and seminal plasma proteins, potentially guiding personalized treatment strategies to improve fertility outcomes in affected individuals.
Keywords
sperm proteome; oxidative stress; secondary male infertility; bioinformatics
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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