Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Differences in Brain Network Topology Based on Alcohol Use History in Adolescents

Haley Kirse
* ORCID logo ,
Mohsen Bahrami
,
Robert Lyday
,
Sean L. Simpson
,
Hope Peterson-Sockwell
,
Jonathan Burdette
,
Paul J Laurienti
ORCID logo
Version 1 : Received: 22 September 2023 / Approved: 25 September 2023 / Online: 25 September 2023 (05:20:04 CEST)

A peer-reviewed article of this Preprint also exists.

Kirse, H.A.; Bahrami, M.; Lyday, R.G.; Simpson, S.L.; Peterson-Sockwell, H.; Burdette, J.H.; Laurienti, P.J. Differences in Brain Network Topology Based on Alcohol Use History in Adolescents. Brain Sci. 2023, 13, 1676. Kirse, H.A.; Bahrami, M.; Lyday, R.G.; Simpson, S.L.; Peterson-Sockwell, H.; Burdette, J.H.; Laurienti, P.J. Differences in Brain Network Topology Based on Alcohol Use History in Adolescents. Brain Sci. 2023, 13, 1676.

Abstract

Approximately 6 million youth aged 12 to 20 consume alcohol monthly in the United States. The effect of alcohol consumption in adolescence on behavior and cognition is heavily researched, however, little is known about how alcohol consumption in adolescence may alter brain function, leading to long-term developmental detriments. In order to investigate differences in brain connectivity associated with alcohol use in adolescents, brain networks were constructed using resting state functional magnetic resonance imaging data collected by the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) from 698 youth (12-21 years, 117 hazardous drinkers and 581 no/low drinkers). Analyses assessed differences in brain network topology based on alcohol consumption in eight pre-defined brain networks, as well as in whole-brain connectivity. Within the central executive network (CEN), basal ganglia network (BGN), and sensorimotor network (SMN), no/low drinkers demonstrated stronger and more frequent connections between highly globally efficient nodes, with fewer and weaker connections between highly clustered nodes. Inverse results were observed within the dorsal attention network (DAN), visual network (VN), and frontotemporal network (FTN), with no/low drinkers demonstrating weaker connections between nodes with high efficiency and increased frequency of clustered nodes compared to hazardous drinkers. Results from this study show clear organizational differences between adolescents with no/low or hazardous alcohol use, suggesting that aberrant connectivity in these brain networks is associated with risky drinking behaviors.

Keywords

alcohol; brain networks; adolescents; resting-state connectivity; fMRI

Subject

Biology and Life Sciences, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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