Version 1
: Received: 6 September 2023 / Approved: 6 September 2023 / Online: 7 September 2023 (11:15:14 CEST)
How to cite:
Koshiba, R.; Kakimoto, K.; Mizuta, N.; Numa, K.; Kinoshita, N.; Nakazawa, K.; Hirata, Y.; Miyazaki, T.; Nakamura, S.; Nishikawa, H. C-Reactive Protein-To-Lymphocyte Ratio Is a Novel Biomarker for Predicting the Long-Term Efficacy of Ustekinumab Treatment in Ulcerative Colitis. Preprints2023, 2023090474. https://doi.org/10.20944/preprints202309.0474.v1
Koshiba, R.; Kakimoto, K.; Mizuta, N.; Numa, K.; Kinoshita, N.; Nakazawa, K.; Hirata, Y.; Miyazaki, T.; Nakamura, S.; Nishikawa, H. C-Reactive Protein-To-Lymphocyte Ratio Is a Novel Biomarker for Predicting the Long-Term Efficacy of Ustekinumab Treatment in Ulcerative Colitis. Preprints 2023, 2023090474. https://doi.org/10.20944/preprints202309.0474.v1
Koshiba, R.; Kakimoto, K.; Mizuta, N.; Numa, K.; Kinoshita, N.; Nakazawa, K.; Hirata, Y.; Miyazaki, T.; Nakamura, S.; Nishikawa, H. C-Reactive Protein-To-Lymphocyte Ratio Is a Novel Biomarker for Predicting the Long-Term Efficacy of Ustekinumab Treatment in Ulcerative Colitis. Preprints2023, 2023090474. https://doi.org/10.20944/preprints202309.0474.v1
APA Style
Koshiba, R., Kakimoto, K., Mizuta, N., Numa, K., Kinoshita, N., Nakazawa, K., Hirata, Y., Miyazaki, T., Nakamura, S., & Nishikawa, H. (2023). C-Reactive Protein-To-Lymphocyte Ratio Is a Novel Biomarker for Predicting the Long-Term Efficacy of Ustekinumab Treatment in Ulcerative Colitis. Preprints. https://doi.org/10.20944/preprints202309.0474.v1
Chicago/Turabian Style
Koshiba, R., Shiro Nakamura and Hiroki Nishikawa. 2023 "C-Reactive Protein-To-Lymphocyte Ratio Is a Novel Biomarker for Predicting the Long-Term Efficacy of Ustekinumab Treatment in Ulcerative Colitis" Preprints. https://doi.org/10.20944/preprints202309.0474.v1
Abstract
Ustekinumab, a new anti-interleukin-12/23 antibody, is an effective treatment for ulcerative colitis; however, data regarding predictive factors of its efficacy are limited. This study aimed to identify biomarkers that can predict the long-term outcome of ustekinumab treatment. We retrospectively reviewed the records of patients with active ulcerative colitis treated with ustekinumab at our hospital from June 2020 to January 2023. We divided patients into non-remission and remission groups, and examined whether baseline biomarkers, including C-reactive protein-to-lymphocyte ratio, and early treatment response could predict clinical remission at week 48 of ustekinumab treatment. Of the 33 patients included in the study, 21 (63.6%) were in clinical remission at week 48 of ustekinumab treatment. The baseline C-reactive protein-to-lymphocyte ratio value was identified as an independent prognostic factor for clinical remission at week 48 (odds ratio: 10, 95% confidence interval: 1.6–62.4, p=0.014), with the cutoff value of 3.353 showing excellent prognostic performance (sensitivity: 71.4%, specificity: 83.3%). Furthermore, the clinical response at week 4 (p=0.009) and that at week 8 (p=0.005) were significantly associated with clinical remission at week 48. The baseline C-reactive protein-to-lymphocyte ratio value and early treatment response are useful biomarkers to predict the long-term efficacy of ustekinumab treatment.
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.