Chowdhury, S.R.; Dey, A.; Mondal, S.; Pawar, S.D.; Ranade, A.; Mahajon, B.; Bora, M.; Rath, C.; Gangwar, M.; Gautam, M.K. Unraveling the Interplay: Intestinal Parasites and Gut Microbiome in Immune-Mediated Bowel Disease. Preprints2023, 2023081346. https://doi.org/10.20944/preprints202308.1346.v1
APA Style
Chowdhury, S.R., Dey, A., Mondal, S., Pawar, S.D., Ranade, A., Mahajon, B., Bora, M., Rath, C., Gangwar, M., & Gautam, M.K. (2023). Unraveling the Interplay: Intestinal Parasites and Gut Microbiome in Immune-Mediated Bowel Disease. Preprints. https://doi.org/10.20944/preprints202308.1346.v1
Chicago/Turabian Style
Chowdhury, S.R., Mayank Gangwar and Manish Kumar Gautam. 2023 "Unraveling the Interplay: Intestinal Parasites and Gut Microbiome in Immune-Mediated Bowel Disease" Preprints. https://doi.org/10.20944/preprints202308.1346.v1
Abstract
Immune-mediated bowel diseases (IMBD), including Ulcerative colitis and Crohn's disease, represent a significant global health burden with their complex etiology and increasing prevalence. The connection between intestinal parasites and the gut microbiome in immune-mediated bowel disease is a complex and evolving field of research. Several studies have demonstrated that intestinal parasites can modulate the composition and function of the gut microbiome. Parasitic infections can result in alterations in the gut microbial community, including changes in microbial diversity, abundance, and metabolic activity. These changes can influence the immune response and contribute to the development of IMBDs. In contrast, the gut microbiome serves a pivotal function in maintaining intestinal homeostasis and immune regulation. Dysbiosis, characterized by changes in the gut microbial composition, has been associated with the pathogenesis of IMBDs. Imbalances in the gut microbiota can result in increased gut permeability, chronic inflammation, and aberrant immune responses, all of which are hallmarks of IMBDs. The bidirectional interaction between intestinal parasites and the gut microbiome further complicates the understanding of immune-mediated bowel diseases. Certain parasites, such as hookworms and Necator americanus, have been found to downregulate immune responses and may have therapeutic potential in treating celiac disease. On the other hand, infections with parasites like Strongyloides stercoralis and Blastocystis have been shown to mimic the symptoms of IBD, highlighting the intricate relationship between parasites and the pathogenesis of these diseases. Additional investigation is required to comprehensively elucidate the mechanisms that underlie the association between intestinal parasites and the gut microbiome in immune-mediated bowel disease. This knowledge could potentially lead to the development of targeted therapeutic strategies that aim to restore gut microbiota homeostasis and alleviate the symptoms of these debilitating conditions. By understanding and harnessing the complex interplay between parasites, the gut microbiome, and the host immune system, researchers may uncover novel approaches for the management and treatment of immune-mediated bowel diseases.
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
*
