Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Estimated pulse wave velocity in the prediction of clinical outcomes in patients undergoing drug-eluting stent implantation

Hack-Lyoung Kiim
* ORCID logo ,
Hyun Sung Joh
,
Woo-Hyun Lim
ORCID logo ,
Jae-Bin Seo
,
Sang-Hyun Kim
,
Joo-Hee Zo
,
Myung-A Kim
Version 1 : Received: 8 August 2023 / Approved: 9 August 2023 / Online: 9 August 2023 (10:15:06 CEST)

A peer-reviewed article of this Preprint also exists.

Kim, H.-L.; Joh, H.S.; Lim, W.-H.; Seo, J.-B.; Kim, S.-H.; Zo, J.-H.; Kim, M.-A. Estimated Pulse Wave Velocity in the Prediction of Clinical Outcomes in Patients Undergoing Drug-Eluting Stent Implantation. J. Clin. Med. 2023, 12, 5855. Kim, H.-L.; Joh, H.S.; Lim, W.-H.; Seo, J.-B.; Kim, S.-H.; Zo, J.-H.; Kim, M.-A. Estimated Pulse Wave Velocity in the Prediction of Clinical Outcomes in Patients Undergoing Drug-Eluting Stent Implantation. J. Clin. Med. 2023, 12, 5855.

Abstract

Background The prognostic value of estimated pulse wave velocity (ePWV) has been infrequently explored in high-risk patient groups. Our study aimed to evaluate the prognostic significance of ePWV among patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stent (DES). Methods A total of 4,119 consecutive subjects who underwent PCI with DES (mean age, 67.1 ± 11.6 years and 33.1% were female) were retrospectively analyzed. ePWV was calculated based on the patient’s age and mean blood pressure. Major adverse cardiovascular event (MACE), including cardiac death, non-fatal myocardial infarction, coronary revascularization, and ischemic stroke, were evaluated. Reults During a median follow-up duration of 3.51 years (interquartile range, 1.35 ~ 6.37 years), there were 746 MACE (18.1%). Multivariable analysis showed that higher ePWV was associated with higher MACE incidence (middle tertile vs. the lowest tertile: hazard ratio [HR], 2.49; 95% confidence interval [CI], 1.81-3.42; P < 0.001; the highest tertile vs. the lowest tertile: HR, 6.18; 95% CI, 4.33-8.80; P < 0.001) The inclusion of ePWV data significantly increased the global chi-square values when added to the clinical information (from 96 to 128; P < 0.001). Conclusion ePWV demonstrated a significant association with MACE in patients who underwent DES implantation. Given its relative simplicity to calculate, ePWV could potentially serve as a valuable instrument for stratifying cardiovascular risk within this high-risk patient population.

Keywords

arterial stiffness; cardiovascular disease; percutaneous coronary intervention; prognosis; pulse wave analysis.

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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