Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Effect of Alpha Lipoic Acid Supplementation on Oxidative Stress- And Lipid Parameters in Women Diagnosed With Low-Grade Squamous Intraepithelial Lesions (LSIL)

Anja Divković
ORCID logo ,
Zinaida Karasalihović
,
Ivana Rumora Samarin
,
Damir Sabitović
,
Kristina Radić
ORCID logo ,
Nikolina Golub
ORCID logo ,
Lovorka Vujić
ORCID logo ,
Marija Grdić Rajković
,
Dubravka Vitali Čepo
* ORCID logo
Version 1 : Received: 2 August 2023 / Approved: 2 August 2023 / Online: 3 August 2023 (10:16:22 CEST)

A peer-reviewed article of this Preprint also exists.

Divković, A.; Karasalihović, Z.; Rumora Samarin, I.; Sabitović, D.; Radić, K.; Golub, N.; Vujić, L.; Rajković, M.G.; Vitali Čepo, D. Effect of Alpha Lipoic Acid Supplementation on Oxidative Stress and Lipid Parameters in Women Diagnosed with Low-Grade Squamous Intraepithelial Lesions (LSILs): A Double-Blind, Randomized, Placebo-Controlled Trial. Antioxidants 2023, 12, 1670. Divković, A.; Karasalihović, Z.; Rumora Samarin, I.; Sabitović, D.; Radić, K.; Golub, N.; Vujić, L.; Rajković, M.G.; Vitali Čepo, D. Effect of Alpha Lipoic Acid Supplementation on Oxidative Stress and Lipid Parameters in Women Diagnosed with Low-Grade Squamous Intraepithelial Lesions (LSILs): A Double-Blind, Randomized, Placebo-Controlled Trial. Antioxidants 2023, 12, 1670.

Abstract

Limited scientific evidence shows that alpha lipoic acid (ALA) can induce regression rates of low-grade squamous intraepithelial lesions (LSIL) but the mechanisms of these effects have not been elucidated. To gain a broader insight into its therapeutic potential and mechanisms of action, the effects of 3-month supplementation with 600 mg of ALA on antioxidant- and lipid status param-eters in 100 patients with LSIL were investigated in randomized placebo-controlled study. Obtained results were discussed in terms of patients’ initial metabolic status and diet quality (particularly nutritional intake of antioxidants). Obtained results showed that oxidative status biomarkers were not significantly affected by ALA supplementation. However, serum superoxide dismutase (SOD) activity was positively affected in the subgroup of patients with higher dietary antioxidant intake. Surprisingly, ALA supplementation resulted with small but statistically significant increase of serum low density lipoprotein (LDL) and observed effect was significantly affected by the initial lipid status of participants. Larger studies are necessary to gain additional insights on the clinical significance of ALA as an antioxidant and hypolipemic agent and to optimize its potential application in LSIL treatment.

Keywords

alpha lipoic acid; lipid status parameters; oxidative stress parameters; LSIL, diet quality index

Subject

Medicine and Pharmacology, Pharmacy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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