Devor, M. Pain in Osteoarthritis: Driven by Intrinsic Rather than Extrinsic Joint Afferents and Why This Should Impact Treatment. Interventional Pain Medicine 2023, 100381, doi:10.1016/j.inpm.2023.100381.
Devor, M. Pain in Osteoarthritis: Driven by Intrinsic Rather than Extrinsic Joint Afferents and Why This Should Impact Treatment. Interventional Pain Medicine 2023, 100381, doi:10.1016/j.inpm.2023.100381.
Devor, M. Pain in Osteoarthritis: Driven by Intrinsic Rather than Extrinsic Joint Afferents and Why This Should Impact Treatment. Interventional Pain Medicine 2023, 100381, doi:10.1016/j.inpm.2023.100381.
Devor, M. Pain in Osteoarthritis: Driven by Intrinsic Rather than Extrinsic Joint Afferents and Why This Should Impact Treatment. Interventional Pain Medicine 2023, 100381, doi:10.1016/j.inpm.2023.100381.
Abstract
Pain in osteoarthritis (OA) results from erosion of joint cartilage, resulting in bone contacting bone without an intervening cushion. The periosteum, including its nociceptive innervation, ends at the border of the cartilage meaning that there is no extrinsic neuronal pathway between the opposing denuded bone surfaces to carry a bone-on-bone pain signal to the brain. The pain signaling pathway must therefore originate in nociceptive sensory endings within the subchondral bone itself. Selective ablation of this intrinsic nerve pathway, using any of a variety of approaches, is expected to permanently eliminate OA pain.
Medicine and Pharmacology, Orthopedics and Sports Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
