Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Current Approach to Non-Alcoholic Steatohepatitis in Type 2 Diabetes Mellitus Patients

Ionelia Sorina Stan
,
Teodora Biciusca
,
Biciusca Viorel
* ORCID logo ,
Ramona Cioboata
,
Adina Mitrea
,
Diana Clenciu
,
Alice Elena Ghenea
ORCID logo ,
Suzana Danoiu
Version 1 : Received: 30 June 2023 / Approved: 3 July 2023 / Online: 3 July 2023 (15:26:47 CEST)

A peer-reviewed article of this Preprint also exists.

Stan, S.I.; Biciusca, T.; Biciusca, V.; Cioboata, R.; Clenciu, D.; Mitrea, A.; Ghenea, A.E.; Danoiu, S. A Current Approach to Non-Alcoholic Steatohepatitis in Type 2 Diabetes Mellitus Patients. Gastroenterol. Insights 2023, 14, 363-382. Stan, S.I.; Biciusca, T.; Biciusca, V.; Cioboata, R.; Clenciu, D.; Mitrea, A.; Ghenea, A.E.; Danoiu, S. A Current Approach to Non-Alcoholic Steatohepatitis in Type 2 Diabetes Mellitus Patients. Gastroenterol. Insights 2023, 14, 363-382.

Abstract

Abstract: (1) Background: The relationship between non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) is bidirectional: NAFLD increases the risk of T2DM, and T2DM promotes the progression of the disease to non-alcoholic steatohepatitis (NASH). (2) Material and methods: We performed a retrospective, open study that included 59 patients with NAFLD and T2DM who were distributed into two groups: 44 (74.57%) patients were diagnosed with HS and 15 (25.42%) patients were diagnosed with NASH. (3) Results: Among the non-specific inflammatory biomarkers statistically significant (p=0.003 respectively p=0.03) higher mean values were recorded in patients with NASH and T2DM in the case of ferritin and the neutrophil percentage-to-albumin ratio (NPAR). (4) Conclusions: Consequently, it is essential to identify alternative "surrogate" markers for the inflammatory process, particularly in individuals with diabetes, as it is a key characteristic of NASH. This need arises from the desire to avoid the risks associated with liver biopsy procedures and to prevent the unpredictable and unfavorable progression of NAFLD in patients with T2DM.

Keywords

non-alcoholic fatty liver disease; type 2 diabetes mellitus; inflammatory process; biological markers

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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