Gut Microbiota Composition and Cardiovascular Disease: A Potential New Therapeutic Target?

Martina Belli; Lucy Barone; Susanna Longo; Francesca Romana Prandi; Dalgisio Lecis; Rocco Mollace; Davide Margonato; Saverio Muscoli; Domenico Sergi; Massimo Federici; Francesco Barillà

doi:10.20944/preprints202306.2222.v1

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preprints.org > medicine and pharmacology > cardiac and cardiovascular systems > doi: 10.20944/preprints202306.2222.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Gut Microbiota Composition and Cardiovascular Disease: A Potential New Therapeutic Target?

Martina Belli

Lucy Barone

Susanna Longo

Francesca Romana Prandi

Version 1 : Received: 29 June 2023 / Approved: 30 June 2023 / Online: 30 June 2023 (11:58:11 CEST)

A peer-reviewed article of this Preprint also exists.

Belli, M.; Barone, L.; Longo, S.; Prandi, F.R.; Lecis, D.; Mollace, R.; Margonato, D.; Muscoli, S.; Sergi, D.; Federici, M.; Barillà, F. Gut Microbiota Composition and Cardiovascular Disease: A Potential New Therapeutic Target? Int. J. Mol. Sci. 2023, 24, 11971. Belli, M.; Barone, L.; Longo, S.; Prandi, F.R.; Lecis, D.; Mollace, R.; Margonato, D.; Muscoli, S.; Sergi, D.; Federici, M.; Barillà, F. Gut Microbiota Composition and Cardiovascular Disease: A Potential New Therapeutic Target? Int. J. Mol. Sci. 2023, 24, 11971.

Abstract

Much evidence reveals an important link between gut microbiota and the heart. In particular, the gut microbiota plays a key role in the onset of cardiovascular (CV) disease, including heart failure (HF). In HF, splanchnic hypoperfusion causes intestinal ischemia resulting in the translocation of bacteria and their metabolites into the blood circulation. Among these, the most important is the Trimethylamine N-Oxide (TMAO), which is responsible through various mechanisms for pathological processes in different organs and tissues. In this review, we summarise the complex interaction between gut microbiota and CV disease, particularly with HF, and the possible strategies to influence its composition and function. Finally, we highlight the potential role of TMAO as a novel prognostic marker and new therapeutic target of HF.

Keywords

Gut microbiota; Cardiovascular diseases; Trimethylamine N-Oxide; Heart failure; Atherosclerosis

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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