Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Treatment Strategies for High-Risk Prostate Cancer - Utility of Combination Therapy of Neoadjuvant Therapy and Radical Prostatectomy to Improve Oncologic Outcomes

Keita Nakane
,
Makoto Kawase
,
Koji Iinuma
,
Yuki Tobisawa
,
Manabu Takai
,
Daiki Kato
,
Kota Kawase
,
Shinichi Takeuchi
,
Naotaka Kumada
,
Sanae Namiki
,
Fumiya Sugino
,
Takayasu Ito
,
Takuya Koie
*
Version 1 : Received: 19 June 2023 / Approved: 19 June 2023 / Online: 19 June 2023 (07:21:19 CEST)

How to cite: Nakane, K.; Kawase, M.; Iinuma, K.; Tobisawa, Y.; Takai, M.; Kato, D.; Kawase, K.; Takeuchi, S.; Kumada, N.; Namiki, S.; Sugino, F.; Ito, T.; Koie, T. Treatment Strategies for High-Risk Prostate Cancer - Utility of Combination Therapy of Neoadjuvant Therapy and Radical Prostatectomy to Improve Oncologic Outcomes. Preprints 2023, 2023061312. https://doi.org/10.20944/preprints202306.1312.v1 Nakane, K.; Kawase, M.; Iinuma, K.; Tobisawa, Y.; Takai, M.; Kato, D.; Kawase, K.; Takeuchi, S.; Kumada, N.; Namiki, S.; Sugino, F.; Ito, T.; Koie, T. Treatment Strategies for High-Risk Prostate Cancer - Utility of Combination Therapy of Neoadjuvant Therapy and Radical Prostatectomy to Improve Oncologic Outcomes. Preprints 2023, 2023061312. https://doi.org/10.20944/preprints202306.1312.v1

Abstract

Prostate cancer (PCa) is most commonly observed in male patients. Although PCa progresses relatively slowly, high-risk PCa is associated with an increased risk of lymph nodes, distant metastases, and PCa-related death. Several guidelines recommend radiation therapy (RT) of the prostate combined with long-term androgen deprivation therapy for high-risk PCa. A comparison of clinical outcomes between radical prostatectomy (RP) and RT for high-risk PCa by propensity score-matched analysis showed that RP had a significantly higher risk of biochemical recurrence than RT. However, the combination of neoadjuvant chemohormonal therapy followed by RP may be more likely to achieve a cure when overall survival is considered the primary endpoint. In this review, we aimed to confirm the oncological outcomes of RP and RT for high-risk PCa and highlight the importance of neoadjuvant therapy followed by RP for high-risk PCa.

Keywords

prostate cancer; high-risk prostate cancer; radical prostatectomy; radiation therapy; neoadjuvant therapy; oncological outcomes

Subject

Medicine and Pharmacology, Urology and Nephrology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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