Version 1
: Received: 15 June 2023 / Approved: 16 June 2023 / Online: 16 June 2023 (14:04:29 CEST)
How to cite:
Fernández-Jaén, T.F.; González de Vega, C.; Sáiz, P.; Björk, P.; Rodríguez-Iñigo, E.; López-Alcorocho, J.M.; Drobnic, F.; Guillén-García, P. Pain Reduction and Tolerance of Type Ii Undenatured Collagen (Uc-Ii) in Patients With Knee Osteoarthritis. Preprints2023, 2023061252. https://doi.org/10.20944/preprints202306.1252.v1
Fernández-Jaén, T.F.; González de Vega, C.; Sáiz, P.; Björk, P.; Rodríguez-Iñigo, E.; López-Alcorocho, J.M.; Drobnic, F.; Guillén-García, P. Pain Reduction and Tolerance of Type Ii Undenatured Collagen (Uc-Ii) in Patients With Knee Osteoarthritis. Preprints 2023, 2023061252. https://doi.org/10.20944/preprints202306.1252.v1
Fernández-Jaén, T.F.; González de Vega, C.; Sáiz, P.; Björk, P.; Rodríguez-Iñigo, E.; López-Alcorocho, J.M.; Drobnic, F.; Guillén-García, P. Pain Reduction and Tolerance of Type Ii Undenatured Collagen (Uc-Ii) in Patients With Knee Osteoarthritis. Preprints2023, 2023061252. https://doi.org/10.20944/preprints202306.1252.v1
APA Style
Fernández-Jaén, T.F., González de Vega, C., Sáiz, P., Björk, P., Rodríguez-Iñigo, E., López-Alcorocho, J.M., Drobnic, F., & Guillén-García, P. (2023). Pain Reduction and Tolerance of Type Ii Undenatured Collagen (Uc-Ii) in Patients With Knee Osteoarthritis. Preprints. https://doi.org/10.20944/preprints202306.1252.v1
Chicago/Turabian Style
Fernández-Jaén, T.F., Franchek Drobnic and Pedro Guillén-García. 2023 "Pain Reduction and Tolerance of Type Ii Undenatured Collagen (Uc-Ii) in Patients With Knee Osteoarthritis" Preprints. https://doi.org/10.20944/preprints202306.1252.v1
Abstract
Osteoarthritis (OA) is the most common cause of pain and disability in adults. Dietary supplements such as undenatured type II collagen (UC-II) have shown to have some benefits in OA treatment. This study aimed to assess changes in pain levels among knee OA patients treated with UC-II for 6 months. Patients with knee OA of any grade were given a daily 40 mg dose of UC-II (CondroArtil®) as a dietary supplement for 6 months. Pain levels were measured using the visual analog scale (VAS) before starting UC-II 6 months thereafter. A total of 100 patients (62/38: male/female) with a mean age of 46.3 ± 13.8 years participated in the study. Most patients (60%) had mild to moderate OA (grade I or II). The UC-II supplementation was shown to significantly reduce pain levels (p<0.001) with a negative correlation between pain reduction and age (p=0.006) and BMI (p=0.049). The OA severity also affected pain reduction (p=0.011), with grade II OA experiencing higher pain levels. Previous physical therapy and food supplements had a significant impact on pain reduction (p=0.017 and p=0.012, respectively). The study suggests that UC-II is an effective treatment for reducing pain in patients with knee OA.
Keywords
Native collagen; Osteoarthritis; Food Supplement
Subject
Medicine and Pharmacology, Orthopedics and Sports Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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