Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Knockdown of DOM/Tip60 Complex Subunits Impairs Male Meiosis of Drosophila melanogaster

Yuri Prozzillo
† ORCID logo ,
Gaia Fattorini
† ,
Diego Ferreri
† ORCID logo ,
Manuela Leo
,
Patrizio Dimitri
* ORCID logo ,
Giovanni Messina
* ORCID logo
†
These authors contributed equally to the work.
Version 1 : Received: 31 March 2023 / Approved: 3 April 2023 / Online: 3 April 2023 (02:33:04 CEST)

A peer-reviewed article of this Preprint also exists.

Prozzillo, Y.; Fattorini, G.; Ferreri, D.; Leo, M.; Dimitri, P.; Messina, G. Knockdown of DOM/Tip60 Complex Subunits Impairs Male Meiosis of Drosophila melanogaster. Cells 2023, 12, 1348. Prozzillo, Y.; Fattorini, G.; Ferreri, D.; Leo, M.; Dimitri, P.; Messina, G. Knockdown of DOM/Tip60 Complex Subunits Impairs Male Meiosis of Drosophila melanogaster. Cells 2023, 12, 1348.

Abstract

ATP-dependent chromatin remodeling complexes are involved in nucleosomes sliding, eviction and/or histone variants incorporation into chromatin to facilitate several cellular and biological processes, including DNA transcription, replication and repair. The DOM/TIP60 chromatin remodeling complex of Drosophila melanogaster contains 18 subunits, including the DOMINO (DOM), an ATPase that catalyzes the ex-change of the canonical H2A with its variant (H2A.V); and TIP60, a lysine-acetyltransferase that acetylates H4, H2A and H2A.V histones. In the last decade, different experimental evidence showed that ATP-dependent chromatin remodeling factors, in addition to their role in chromatin organization, have a functional relevance in cell division. In particular, emerging studies suggested direct roles of ATP-dependent chromatin remodeling complex subunits in controlling mitosis and cytokinesis in both humans and D. melanogaster. However, little is known about their possible involvement during meiosis Meiotic chromosomes non-disjunction led to aneuploid offspring, which are often inviable/poorly viable or sterile due to gene dosage imbalance. Therefore, studying the role of DOM/TIP60 complex in D. melanogaster meiosis can provide new insights on our understanding of the molecular mechanisms underlying cell division control in gametogenesis.

Keywords

TIP60; DOMINO; ATPase; Drosophila male meiosis; chromatin remodeling; cell division; epigenetics

Subject

Biology and Life Sciences, Cell and Developmental Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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