Version 1
: Received: 13 February 2023 / Approved: 17 February 2023 / Online: 17 February 2023 (13:01:18 CET)
How to cite:
Yi, H.; Yang, Z.; Bramlage, L. C.; Bryan, L. R. Morphology and Hemodynamics of Cerebral Arteries and Aneurysms in a Pair of Monozygotic Twins. Preprints2023, 2023020311. https://doi.org/10.20944/preprints202302.0311.v1
Yi, H.; Yang, Z.; Bramlage, L. C.; Bryan, L. R. Morphology and Hemodynamics of Cerebral Arteries and Aneurysms in a Pair of Monozygotic Twins. Preprints 2023, 2023020311. https://doi.org/10.20944/preprints202302.0311.v1
Yi, H.; Yang, Z.; Bramlage, L. C.; Bryan, L. R. Morphology and Hemodynamics of Cerebral Arteries and Aneurysms in a Pair of Monozygotic Twins. Preprints2023, 2023020311. https://doi.org/10.20944/preprints202302.0311.v1
APA Style
Yi, H., Yang, Z., Bramlage, L. C., & Bryan, L. R. (2023). Morphology and Hemodynamics of Cerebral Arteries and Aneurysms in a Pair of Monozygotic Twins. Preprints. https://doi.org/10.20944/preprints202302.0311.v1
Chicago/Turabian Style
Yi, H., Luke C Bramlage and Ludwig R Bryan. 2023 "Morphology and Hemodynamics of Cerebral Arteries and Aneurysms in a Pair of Monozygotic Twins" Preprints. https://doi.org/10.20944/preprints202302.0311.v1
Abstract
The contribution of genetic and environmental factors to the pathophysiology of cerebral aneurysms in monozygotic twins is under-reported and presents ambiguous arguments. The morphology and hemodynamics of neurovascular arteries in a pair of monozygotic twins (MTs) were investigated to reveal the underlying mechanisms. Four arterial models were reconstructed for the twin A-right brain and left brain, twin B-left brain, and B-left brain without anterior cerebral arteries based on preclinical scanned information. Subsequently, the dimensions, configurations and outlined curves of the three-perspective geometries were compared between the MTs. Adopting an in-vitro validated numerical cerebral aneurysm model, hemodynamic patterns were investigated and compared in the MT models, respectively. Morphological comparisons of the MTs show the size and shape of cerebral arteries exist significant differences, despite of the expected genetic similarities. These differences can be attributed to variations during embryological development and external environmental influences. Qualitatively and generally, numerical results indicate the MTs have some hemodynamic similarities (e.g., time-averaged pressure (TAP) distributions (~13400 Pa), and oscillatory shear index (0~0.49), but present significant differences in specific local arteries due to morphological variances. Specifically, the difference in the volumetric blood flow rate in corresponding arteries between the MTs is from 16% (smallest) in anterior choroidal artery (AChA) to 221% (largest) in the ophthalmic artery (OphA), varying with specific compared arteries. Also, the registered hemodynamic indicators, such as the maximum time-averaged wall shear stress (TWSS) (53.6 Pa vs. 37.8 Pa), and different local OSI distributions were observed between the MTs. The findings revealed that morphological variations in MTs could be generated by embryological and environmental factors, thus assuming they share the identical morphology in cardiovascular and neurovascular systems may lead to significant misevaluations in hemodynamics quantifications and further lesions.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
