Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Motoric Cognitive Risk Syndrome, Subtypes and 8-year all-cause Mortality in Aging Phenotypes: The Salus in Apulia Study

Ilaria Bortone
* ORCID logo ,
Roberta Zupo
ORCID logo ,
Fabio Castellana
ORCID logo ,
Simona Aresta
,
Luisa Lampignano
ORCID logo ,
Sabrina Sciarra
,
Chiara Griseta
,
Tommaso Antonio Stallone
,
Giancarlo Sborgia
,
Madia Lozupone
ORCID logo ,
Francesco Panza
ORCID logo ,
Gianvito Lagravinese
,
Petronilla Battista
,
Rodolfo Sardone
ORCID logo
Version 1 : Received: 12 April 2022 / Approved: 14 April 2022 / Online: 14 April 2022 (12:19:35 CEST)

A peer-reviewed article of this Preprint also exists.

Bortone, I.; Zupo, R.; Castellana, F.; Aresta, S.; Lampignano, L.; Sciarra, S.; Griseta, C.; Stallone, T.A.; Sborgia, G.; Lozupone, M.; Panza, F.; Lagravinese, G.; Battista, P.; Sardone, R. Motoric Cognitive Risk Syndrome, Subtypes and 8-Year All-Cause Mortality in Aging Phenotypes: The Salus in Apulia Study. Brain Sci. 2022, 12, 861. Bortone, I.; Zupo, R.; Castellana, F.; Aresta, S.; Lampignano, L.; Sciarra, S.; Griseta, C.; Stallone, T.A.; Sborgia, G.; Lozupone, M.; Panza, F.; Lagravinese, G.; Battista, P.; Sardone, R. Motoric Cognitive Risk Syndrome, Subtypes and 8-Year All-Cause Mortality in Aging Phenotypes: The Salus in Apulia Study. Brain Sci. 2022, 12, 861.

Abstract

Background: This study aims to set out key clinical features of different Motoric Cognitive Risk (MCR) subtypes based on individual quantitative measures of cognitive impairment and to compare their predictive power on survival over an 8-year observation time. Methods: We analyzed data from a population-based study of 1138 subjects aged 65 years and older in south Italy. These individuals were targeted and allocated to subtypes of the MCR phenotype according to the slowness criterion plus one other different cognitive domain for each characterized phenotype. Clinical evaluation and laboratory assays, along with a comprehensive battery of neuropsychological and physical tests, completed the sample investigation. Results: MCR prevalence was found to be 9.8% (N=112), 3.6% (N=41), 3.4% (N=39), and 1.8% (N=21) for the MCR, MCR-GlobalFunction, MCR-StructuredSCC, and MCR-SCC&GlobalFunction, respectively. Univariate Cox survival analysis showed an association only of the MCR-GlobalFunction subtype with a significant, 1.5-fold increased risk of overall death as compared to the other counterparts (HR 2.53, 95%CI 1.28 to 4.99, P-value<0.01) over an 8-year observation period, even after major adjustment (HR 2.02, 95%CI 1.02 to 4.02). Conclusions: MCR phenotypes assigned to the MMSE cognitive domain are more likely to have an increased risk of overall mortality, 1.5-fold higher than counterparts, over 8-year observation.

Keywords

frailty; older people; cognitive impairment; assessment; gait

Subject

Medicine and Pharmacology, Orthopedics and Sports Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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