Version 1
: Received: 20 August 2021 / Approved: 23 August 2021 / Online: 23 August 2021 (10:43:23 CEST)
How to cite:
Peregrina, A.; Martins-Lourenço, J.; Freitas, F.; M. Reis, M.A.; Arraiano, C.M. Post-Transcriptional Control in the Regulation of Polyhydroxyalkanoates Synthesis. Preprints2021, 2021080426. https://doi.org/10.20944/preprints202108.0426.v1
Peregrina, A.; Martins-Lourenço, J.; Freitas, F.; M. Reis, M.A.; Arraiano, C.M. Post-Transcriptional Control in the Regulation of Polyhydroxyalkanoates Synthesis. Preprints 2021, 2021080426. https://doi.org/10.20944/preprints202108.0426.v1
Peregrina, A.; Martins-Lourenço, J.; Freitas, F.; M. Reis, M.A.; Arraiano, C.M. Post-Transcriptional Control in the Regulation of Polyhydroxyalkanoates Synthesis. Preprints2021, 2021080426. https://doi.org/10.20944/preprints202108.0426.v1
APA Style
Peregrina, A., Martins-Lourenço, J., Freitas, F., M. Reis, M.A., & Arraiano, C.M. (2021). Post-Transcriptional Control in the Regulation of Polyhydroxyalkanoates Synthesis. Preprints. https://doi.org/10.20944/preprints202108.0426.v1
Chicago/Turabian Style
Peregrina, A., Maria A. M. Reis and Cecília M. Arraiano. 2021 "Post-Transcriptional Control in the Regulation of Polyhydroxyalkanoates Synthesis" Preprints. https://doi.org/10.20944/preprints202108.0426.v1
Abstract
The large production of non-degradable petrol-based plastics has become a major global issue due to its environmental pollution. Biopolymers produced by microorganisms such as polyhydroxyalkanoates (PHAs) are gaining potential as a sustainable alternative, but the high cost associated to their industrial production has been a limiting factor. Post-transcriptional regulation is a key step to control gene expression in changing environments and has been reported to play a major role in numerous cellular processes. However, limited reports are available concerning the regulation of PHA accumulation in bacteria, and many essential regulatory factors still need to be identified. Here, we review studies where the synthesis of PHA has been reported to be regulated at the post-transcriptional level, and we analyze the RNA-mediated networks involved. Finally, we discuss the forthcoming research on riboregulation, synthetic and metabolic engineering which could lead to improved strategies for PHAs synthesis in industrial production, thereby reducing the costs currently associated with this procedure.
Keywords
Polyhydroxyalkanoates; mcl-PHA; scl-PHA; Post-transcriptional regulation; Riboregulation; Small non-coding RNAs
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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