Kaur, R.; Shropshire, J. D.; Cross, K. L.; Leigh, B.; Mansueto, A. J.; Stewart, V.; Bordenstein, S. R.; Bordenstein, S. R. Living in the Endosymbiotic World of Wolbachia: A Centennial Review. Cell Host & Microbe, 2021, 29, 879–893. https://doi.org/10.1016/j.chom.2021.03.006.
Kaur, R.; Shropshire, J. D.; Cross, K. L.; Leigh, B.; Mansueto, A. J.; Stewart, V.; Bordenstein, S. R.; Bordenstein, S. R. Living in the Endosymbiotic World of Wolbachia: A Centennial Review. Cell Host & Microbe, 2021, 29, 879–893. https://doi.org/10.1016/j.chom.2021.03.006.
Kaur, R.; Shropshire, J. D.; Cross, K. L.; Leigh, B.; Mansueto, A. J.; Stewart, V.; Bordenstein, S. R.; Bordenstein, S. R. Living in the Endosymbiotic World of Wolbachia: A Centennial Review. Cell Host & Microbe, 2021, 29, 879–893. https://doi.org/10.1016/j.chom.2021.03.006.
Kaur, R.; Shropshire, J. D.; Cross, K. L.; Leigh, B.; Mansueto, A. J.; Stewart, V.; Bordenstein, S. R.; Bordenstein, S. R. Living in the Endosymbiotic World of Wolbachia: A Centennial Review. Cell Host & Microbe, 2021, 29, 879–893. https://doi.org/10.1016/j.chom.2021.03.006.
Abstract
The most widespread intracellular bacteria in the animal kingdom are maternally-inherited endosymbionts of the genus Wolbachia. Their prevalence in arthropods and nematodes worldwide and a stunning arsenal of parasitic and mutualistic adaptations make these bacteria a biological archetype for basic studies of symbiosis and applied outcomes for curbing human and agricultural diseases. Here, we conduct a summative, centennial analysis of living in the Wolbachia world. We synthesize literature on Wolbachia’s host range, phylogenetic diversity, genomics, cell biology, and applications to filarial, arboviral, and agricultural diseases. We also review the mobilome of Wolbachia including phage WO and its essentiality to hallmark phenotypes in arthropods. Finally, the Wolbachia system is an exemplar for discovery-based science education using biodiversity, biotechnology, and bioinformatics lessons. As we approach a century of Wolbachia research, applications, and education, the interdisciplinary science and knowledge from this symbiosis stand as a model for consolidating and teaching the integrative rules of endosymbiotic life.
Keywords
Wolbachia; phage WO; cytoplasmic incompatibility; male killing; feminization; parthenogenesis; evolution; vector control
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
,
,
,
,
,
,
