Version 1
: Received: 8 July 2020 / Approved: 10 July 2020 / Online: 10 July 2020 (07:51:23 CEST)
How to cite:
Myngbay, A.; Manarbek, L.; Ludbrook, S.B.; Kunz, J. The Role of Collagen Triple Helix Repeat-Containing 1 Protein (CTHRC1) in Rheumatoid Arthritis. Preprints2020, 2020070206. https://doi.org/10.20944/preprints202007.0206.v1
Myngbay, A.; Manarbek, L.; Ludbrook, S.B.; Kunz, J. The Role of Collagen Triple Helix Repeat-Containing 1 Protein (CTHRC1) in Rheumatoid Arthritis. Preprints 2020, 2020070206. https://doi.org/10.20944/preprints202007.0206.v1
Myngbay, A.; Manarbek, L.; Ludbrook, S.B.; Kunz, J. The Role of Collagen Triple Helix Repeat-Containing 1 Protein (CTHRC1) in Rheumatoid Arthritis. Preprints2020, 2020070206. https://doi.org/10.20944/preprints202007.0206.v1
APA Style
Myngbay, A., Manarbek, L., Ludbrook, S.B., & Kunz, J. (2020). The Role of Collagen Triple Helix Repeat-Containing 1 Protein (CTHRC1) in Rheumatoid Arthritis. Preprints. https://doi.org/10.20944/preprints202007.0206.v1
Chicago/Turabian Style
Myngbay, A., Steve B. Ludbrook and Jeannette Kunz. 2020 "The Role of Collagen Triple Helix Repeat-Containing 1 Protein (CTHRC1) in Rheumatoid Arthritis" Preprints. https://doi.org/10.20944/preprints202007.0206.v1
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease, causing inflammation of joints, cartilage destruction and bone erosion. Biomarkers and new drug targets are actively sought and progressed to improve available options for patient treatment. The Collagen Triple Helix Repeat Containing 1 protein (CTHRC1) may have an important role as a biomarker for rheumatoid arthritis, as CTHRC1 protein concentration is significantly elevated in the peripheral blood of rheumatoid arthritis patients, compared to osteoarthritis (OA) patients and healthy individuals. CTHRC1 is a secreted glycoprotein that promotes cell migration and has been implicated in arterial tissue-repair processes. Furthermore, high CTHRC1 expression is observed in many types of cancer and this is associated with cancer metastasis to the bone and poor prognosis. However, the function of CTHRC1 in RA is still largely undefined. The aim of this review is to summarize recent findings on the role of CTHRC1 as a potential biomarker and pathogenic driver of RA progression that may be linked to the pathogenic behavior of fibroblast-like synoviocytes, cartilage destruction, and bone erosion.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
