Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs

Ujjwal Neogi; Kyle J. Hill; Anoop T. Ambikan; Xiao Heng; Thomas P. Quinn; Siddappa N. Byrareddy; Anders Sönnerborg; Stefan G. Sarafianos; Kamal Singh

doi:10.20944/preprints202004.0184.v1

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preprints.org > medicine and pharmacology > medicine and pharmacology > doi: 10.20944/preprints202004.0184.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs

Siddappa N. Byrareddy

Anders Sönnerborg

Stefan G. Sarafianos

Kamal Singh

Version 1 : Received: 11 April 2020 / Approved: 12 April 2020 / Online: 12 April 2020 (05:36:40 CEST)

How to cite: Neogi, U.; Hill, K.J.; Ambikan, A.T.; Heng, X.; Quinn, T.P.; Byrareddy, S.N.; Sönnerborg, A.; Sarafianos, S.G.; Singh, K. Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs. Preprints 2020, 2020040184. https://doi.org/10.20944/preprints202004.0184.v1 Neogi, U.; Hill, K.J.; Ambikan, A.T.; Heng, X.; Quinn, T.P.; Byrareddy, S.N.; Sönnerborg, A.; Sarafianos, S.G.; Singh, K. Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs. Preprints 2020, 2020040184. https://doi.org/10.20944/preprints202004.0184.v1

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MDPI and ACS Style

Neogi, U.; Hill, K.J.; Ambikan, A.T.; Heng, X.; Quinn, T.P.; Byrareddy, S.N.; Sönnerborg, A.; Sarafianos, S.G.; Singh, K. Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs. Preprints 2020, 2020040184. https://doi.org/10.20944/preprints202004.0184.v1

APA Style

Neogi, U., Hill, K.J., Ambikan, A.T., Heng, X., Quinn, T.P., Byrareddy, S.N., Sönnerborg, A., Sarafianos, S.G., & Singh, K. (2020). Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs. Preprints. https://doi.org/10.20944/preprints202004.0184.v1

Chicago/Turabian Style

Neogi, U., Stefan G. Sarafianos and Kamal Singh. 2020 "Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs" Preprints. https://doi.org/10.20944/preprints202004.0184.v1

Abstract

Coronaviruses (CoVs) are positive-stranded RNA viruses that infect humans and animals. Infection by CoVs such as HCoV-229E, -NL63, -OC43 and -HKUI1 leads to the common cold, short lasting rhinitis, cough, sore throat and fever. However, CoVs such as Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and the newest SARS-CoV-2 (the causative agent of COVID-19) lead to severe and deadly diseases with mortality rates ranging between ~1 to 35% depending on factors such as age and pre-existing conditions. Despite continuous global health threats to human, there are no approved vaccines or drugs targeting human CoVs, and the recent outbreak of COVID-19 emphasizes an urgent need for therapeutic interventions. Using computational and bioinformatics tools, here we present the feasibility of reported broad-spectrum RNA polymerase inhibitors as anti- SARS-CoV-2 drugs targeting its main RNA polymerase, suggesting that investigational and approved nucleoside RNA polymerase inhibitors have potential as anti-SARS-CoV-2 drugs. However, we note that it is also possible for SARS-CoV-2 to evolve and acquire drug resistance mutations against these nucleoside inhibitors.

Keywords

Coronavirus; SARS-CoV; MERS-CoV; SARS-CoV-2; COVID-19; RNA polymerase; nsp12

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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