Cancer Cells’ Low Sensitivity to Oxalate

Qiuyun Liu; Xiaoxia Li; Tianlun Lei; Yilin Zhang; Man Tang; Meng Xing; Jingli Peng; Min Fu; Li Xu; Wenliang Zhou

doi:10.20944/preprints202003.0390.v1

Preprint Short Note Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 25 March 2020 / Approved: 26 March 2020 / Online: 26 March 2020 (14:20:51 CET)

The Warburg effect refers to the phenomenon that cancer cells produce energy via glycolysis instead of cellular respiration. Glycolysis generated no net protons. The Warburg effect may be malignant cells’ built-in mechanism to antagonize the buildup of protons via Krebs cycle and other pathways with compromised cellular respiration. Data described in this study indicated that cancer cells were less sensitive to the presence of oxalate than non-cancer model cell lines 16HBE14o- and HaCaT. Malignant cells may resort on organic acids such as oxalate and their calcium salts to antagonize strong acids. This experiment sheds light on the role of Warburg effect in cancer cell metabolism and homeostasis.

Warburg effect; Protons; Calcium oxalate; Antagonization

Biology and Life Sciences, Biochemistry and Molecular Biology

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Cancer Cells’ Low Sensitivity to Oxalate

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