Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Human Milk Oligosaccharides: 2’-fucosyllactose (2’-FL) and Lacto-N-neotetraose (LNnT) in Infant Formula

Y. Vandenplas
* ORCID logo ,
B. Berger
,
V.P. Carnielli
,
J. Ksiazyk
ORCID logo ,
H. Lagström
,
M. Sanchez Luna
,
N. Migacheva
,
J.M.M. Mosselmans
,
J.C. Picaud
ORCID logo ,
M. Possner
,
A. Singhal
,
M. Wabitsch
Version 1 : Received: 23 July 2018 / Approved: 23 July 2018 / Online: 23 July 2018 (11:34:09 CEST)

A peer-reviewed article of this Preprint also exists.

Vandenplas, Y.; Berger, B.; Carnielli, V.P.; Ksiazyk, J.; Lagström, H.; Sanchez Luna, M.; Migacheva, N.; Mosselmans, J.-M.; Picaud, J.-C.; Possner, M.; Singhal, A.; Wabitsch, M. Human Milk Oligosaccharides: 2′-Fucosyllactose (2′-FL) and Lacto-N-Neotetraose (LNnT) in Infant Formula. Nutrients 2018, 10, 1161. Vandenplas, Y.; Berger, B.; Carnielli, V.P.; Ksiazyk, J.; Lagström, H.; Sanchez Luna, M.; Migacheva, N.; Mosselmans, J.-M.; Picaud, J.-C.; Possner, M.; Singhal, A.; Wabitsch, M. Human Milk Oligosaccharides: 2′-Fucosyllactose (2′-FL) and Lacto-N-Neotetraose (LNnT) in Infant Formula. Nutrients 2018, 10, 1161.

Abstract

Introduction The authors reviewed the published evidence on the presence of oligosaccharides in human milk (HMO) and their benefits in in vitro and in vivo studies, as well as to evaluate published data on the addition of some of HMOs to infant formula. Method PubMed was searched from inception to April 2018 Results The presence of HMOs is a dynamic process, determined by many factors such as duration of lactation, environmental and genetic factors. HMOs may support immune function development and provide protection against infectious diseases directly through the interaction of the gut epithelial cells or indirectly through the modulation of the gut microbiota, including the stimulation of the bifidobacteria. Only a few of the many HMOs can be made industrially, and are added to infant formula. They have been shown to be safe and well tolerated, including normal growth and a trend towards health benefit. Conclusions HMOs are one of the major differences between cow’s milk and human milk , and evidence indicates that these components do have a health promoting benefit. The addition of one or two of these components to infant formula is safe, and brings infant formula closer to human milk.

Keywords

breast feeding; formula feeding; human milk oligosaccharide; 2’-fucosyllactose; Lacto-N-neotetraose; microbiota; bifidobacteria

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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