Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Acute Administration of Caffeine: The Effect on Motor Coordination, Higher Brain Cognitive Functions and the Social Behavior of BLC57 Mice

Sayed Almosawi
ORCID logo ,
Hasan Baksh
,
Abdulrahman Qareeballah
ORCID logo ,
Faisal Falamarzi
,
Bano Alsaleh
,
Malak Alrabaani
,
Ali Aljalban
,
Sadiq Mahdi
,
Amer Kamal
* ORCID logo
Version 1 : Received: 3 June 2018 / Approved: 4 June 2018 / Online: 4 June 2018 (13:02:34 CEST)

How to cite: Almosawi, S.; Baksh, H.; Qareeballah, A.; Falamarzi, F.; Alsaleh, B.; Alrabaani, M.; Aljalban, A.; Mahdi, S.; Kamal, A. Acute Administration of Caffeine: The Effect on Motor Coordination, Higher Brain Cognitive Functions and the Social Behavior of BLC57 Mice. Preprints 2018, 2018060045. https://doi.org/10.20944/preprints201806.0045.v1 Almosawi, S.; Baksh, H.; Qareeballah, A.; Falamarzi, F.; Alsaleh, B.; Alrabaani, M.; Aljalban, A.; Mahdi, S.; Kamal, A. Acute Administration of Caffeine: The Effect on Motor Coordination, Higher Brain Cognitive Functions and the Social Behavior of BLC57 Mice. Preprints 2018, 2018060045. https://doi.org/10.20944/preprints201806.0045.v1

Abstract

Heavy caffeine consumption is associated with adverse health effects. The effects of moderate and high doses of caffeine mixed with drinking water on the motor coordination, learning and memory and the social behavior in mice were studied in mice. Animals were divided into 3 groups: control group, moderate dose group (Ac MD) and high dose group (Ac HD). The animals were tested after 7 days of caffeine administration. Rota rod test for motor coordination showed that the mice of the moderate dose group could stay more time on the rotating rod before they fall than the control group and the high dose group. Water maze test for learning and memory showed better performance of mice receiving moderate dose of caffeine compared to the other groups. Animals that were administered moderate as well as high doses of caffeine showed no sociability and no preference for social novelty in the three-chamber test used to test the social behavior. In elevated plus maze, control animals showed no anxiety- like behavior while mice administered with caffeine were both showing anxiety-like behaviors. We concluded that acute administration of moderate dose of caffeine to mice could enhance their spatial memory and motor coordination. High doses however caused defects in memory and learning. The social behavior as the level of anxiety and sociability was affected negatively by moderate as well as high dose caffeine administration.

Keywords

caffeine; cognition; motor coordination; memory; social behavior; mice

Subject

Social Sciences, Cognitive Science

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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