Preprint Article Version 1 NOT YET PEER-REVIEWED

TTF1, in the Form of Nanoparticles, Inhibits Angiogenesis, Cell Migration and Cell Invasion in VitroandIn Vivoin Human Hepatoma through STAT3 Regulation

  1. College of Medicine, Yanbian University, Yanji 133000, China
  2. Basic Medical College, Jilin Medical University, Jilin 132013, China
Version 1 : Received: 8 November 2016 / Approved: 9 November 2016 / Online: 9 November 2016 (10:21:43 CET)

A peer-reviewed article of this Preprint also exists.

Xiao, B.; Lin, D.; Zhang, X.; Zhang, M.; Zhang, X. TTF1, in the Form of Nanoparticles, Inhibits Angiogenesis, Cell Migration and Cell Invasion In Vitro and In Vivo in Human Hepatoma through STAT3 Regulation. Molecules 2016, 21, 1507. Xiao, B.; Lin, D.; Zhang, X.; Zhang, M.; Zhang, X. TTF1, in the Form of Nanoparticles, Inhibits Angiogenesis, Cell Migration and Cell Invasion In Vitro and In Vivo in Human Hepatoma through STAT3 Regulation. Molecules 2016, 21, 1507.

Journal reference: Molecules 2016, 21, 1507
DOI: 10.3390/molecules21111507

Abstract

TTF1-NP(5,2′,4′-trihydroxy-6,7,5′-trimethoxyflavone nanoparticles), derived from the traditional Changbai Mountain medicinal plant Sorbaria sorbifolia (SS), has been showedits anti-cancer effect in various liver cancer cell types and tissues. The present study was designed to evaluate the antitumor mechanism of the TTF1-NP against HepG2 hepatoma cells and HepG2 cells-induced hepatocarcinoma (HCC) in nude mouse model. Here we demonstrated that TTF1-NP inhibits tube formation of HUVECs and HepG2 cell migration and invasion, and inhibits tumor growth in nude mice implanted with HepG2 cells through the downregulation of STAT3 protein and activation, along with VEGF, KDR, bFGF, MMP2 and MMP9 levels. We further revealed that TTF1-NP decreased the DNA-binding capacity of STAT3. Together our results provide a mechanism by which TTF1-NP suppresses cancer cell migration, invasion and angiogenesis through the action of STAT3 and suggests TTF1-NP as a potential therapy for hepatocellular cancer treatment.

Subject Areas

angiogenesis; cell invasion; cell migration; Flavone derivative (TTF1); hepatoma; STAT3

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