Preprint Article Version 1 NOT YET PEER-REVIEWED

Quantifying Mosaic Development: Towards an Evo-Devo Postmodern Synthesis of the Evolution of Development via Differentiation Trees of Embryos

  1. Orthogonal Research, Champaign, IL 61821, USA
  2. OpenWorm, San Diego, CA, USA
  3. Gulf Specimen Marine Laboratory & Aquarium, 222 Clark Drive, Panacea, FL 32346, USA
  4. C.S. Mott Center for Human Growth & Development, Department of Obstetrics & Gynecology, Wayne State University, 275 E. Hancock, Detroit, MI 48201, USA
Version 1 : Received: 9 August 2016 / Approved: 10 August 2016 / Online: 10 August 2016 (11:36:39 CEST)

A peer-reviewed article of this Preprint also exists.

Alicea, B.; Gordon, R. Quantifying Mosaic Development: Towards an Evo-Devo Postmodern Synthesis of the Evolution of Development via Differentiation Trees of Embryos.Biology 2016, 5, 33. Alicea, B.; Gordon, R. Quantifying Mosaic Development: Towards an Evo-Devo Postmodern Synthesis of the Evolution of Development via Differentiation Trees of Embryos.Biology 2016, 5, 33.

Journal reference: Biology 2016, 5, 33
DOI: 10.3390/biology5030033

Abstract

Embryonic development proceeds through a series of differentiation events. The mosaic version of this process (binary cell divisions) can be analyzed by comparing early development of Ciona intestinalis and Caenorhabditis elegans. To do this, we reorganize lineage trees into differentiation trees using the graph theory ordering of relative cell volume. Lineage and differentiation trees provide us with means to classify each cell using binary codes. Extracting data characterizing lineage tree position, cell volume, and nucleus position for each cell during early embryogenesis, we conduct several statistical analyses, both within and between taxa. We compare both cell volume distributions and cell volume across developmental time within and between single species and assess differences between lineage tree and differentiation tree orderings. This enhances our understanding of the differentiation events in a model of pure mosaic embryogenesis and its relationship to evolutionary conservation. We also contribute several new techniques for assessing both differences between lineage trees and differentiation trees, and differences between differentiation trees of different species. The results suggest that at the level of differentiation trees, there are broad similarities between distantly related mosaic embryos that might be essential to understanding evolutionary change and phylogeny reconstruction. Differentiation trees may therefore provide a basis for an
Evo-Devo Postmodern Synthesis.

Subject Areas

developmental biology; computational biology; lineage trees; embryogenesis; biological complexity

Readers' Comments and Ratings (0)

Discuss and rate this article
Views 165
Downloads 142
Comments 0
Metrics 0
Discuss and rate this article

×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.