The primary goal of picture compression is to reduce the amount of unused image data while still storing or transmitting it in a format that is appropriate. The compression of raw binary data is quite different from the compression of a picture, and these differences may be rather substantial. In light of this, compression is often regarded as an essential technique for the purposes of both data storage an d transmission in order to mitigate the excessive amounts of data that are generated by these images. In order to transmit enormous datasets, particularly for the purposes of telemedicine and teleradiology, one needs a significant amount of storage capacity as well as an expansive network. As a result, compression is an important aspect of medical imaging. In addition to the importance of compression, the quality of the photos themselves is also an essential factor in the success of analysis. In addition to this, the amount of time necessary to compress the photographs before sending them should be reduced.

Chronic Hepatitis B (CHB) Virus infection is major etiological factor for liver cirrhosis and/ or liver cancer. The viral protein, major contributor in predisposition of chronicity and Hepatocellular Carcinoma (HCC) is Hepatitis B x (HBx) protein. Its dynamic subcellular distribution to an extent determines its multifactorial role. It is a regulatory protein which modulates viral as well as host machinery in favours to HBV persistence. An insight on HBx stabilising factors is critical for therapeutic purpose. The precise role of HBx in the pathogenesis of Chronicity of HBV is not known. Summary: This review comprehensively summarizing different mechanisms and their regulation by HBx protein with respect to chronicity and HCC emphasising viral persistence. Key Messages 1. HBx is a key protein for viral persistence. 2. Dynamic subcellular distribution of HBx determines its function. 3. HBx modulates cellular machinery to favours HBV survival. 4. HBx affects various intermediary mechanisms contributing to disease progression. 5. HBx may be a potent target to prevent the disease progression towards HCC.