Gamma titanium aluminides (γ-TiAl) present an excellent behaviour under high temperature conditions, being a feasible alternative to nickel-based superalloy components in aeroengine sector. However, considered as a difficult to cut material, process cutting parameters require special study to guarantee components quality. In this work, developed drilling mechanistic model is a useful tool in order to predict drilling force (Fz) and torque (Tc) for optimal drilling conditions determination. The model is validated for three types of Gamma-TiAl alloys. Integral hard metal end-drilling tools and different cutting parameters (feeds and cutting speeds) are tested in three different sized holes for each alloy.