Single-Molecule Tracking for Live Cell without Immobilization or Significant Hydrodynamic Flow by Simulations: Thermodynamic Jitter

Zeno Földes-Papp; Gerd Baumann

doi:10.20944/preprints202405.0395.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 29 April 2024 / Approved: 7 May 2024 / Online: 7 May 2024 (13:08:33 CEST)

Abstract: Although experimental attempts to measure a single molecule/particle at room temperature or under physiological conditions without immobilization, for example on a surface, or without hydrodynamic flow have so far failed, this failure has given impetus to the underlying theory of Brownian motion towards its stochastic due to diffusion. Quantifying the thermodynamic jitter of molecules/particles inspires many and forms the theoretical basis of single-molecule/single-particle biophysics and biochemistry. For the first time, our simulation results for a live cell (cytoplasm) show that the tracks of individual single molecules are localized in Brownian motion, while there is fanning out in fractal diffusion (anomalous diffusion).

Individual molecule tracking; diffusion; thermodynamic jitter; live cell, cytoplasm, liquids, room temperature, continuous-time random walk (CTRW); Brownian motion/diffusion anomalous motion/diffusion; computer simulations

Physical Sciences, Biophysics

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Single-Molecule Tracking for Live Cell without Immobilization or Significant Hydrodynamic Flow by Simulations: Thermodynamic Jitter

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