Version 1
: Received: 28 April 2024 / Approved: 29 April 2024 / Online: 29 April 2024 (09:55:51 CEST)
How to cite:
Wang, X.; Feng, J.-H.; Zeng, C.-M.; Zhang, Z.-S.; Cao, F.-L.; Zhang, W.-H.; Chen, J.-X.; Mao, Y.; Young, D. J. [FeIIICl(TMPPH2)][FeIIICl4]2: A Stand-Alone Molecular Nanomedicine that Induces High Cytotoxicity by Ferroptosis. Preprints2024, 2024041891. https://doi.org/10.20944/preprints202404.1891.v1
Wang, X.; Feng, J.-H.; Zeng, C.-M.; Zhang, Z.-S.; Cao, F.-L.; Zhang, W.-H.; Chen, J.-X.; Mao, Y.; Young, D. J. [FeIIICl(TMPPH2)][FeIIICl4]2: A Stand-Alone Molecular Nanomedicine that Induces High Cytotoxicity by Ferroptosis. Preprints 2024, 2024041891. https://doi.org/10.20944/preprints202404.1891.v1
Wang, X.; Feng, J.-H.; Zeng, C.-M.; Zhang, Z.-S.; Cao, F.-L.; Zhang, W.-H.; Chen, J.-X.; Mao, Y.; Young, D. J. [FeIIICl(TMPPH2)][FeIIICl4]2: A Stand-Alone Molecular Nanomedicine that Induces High Cytotoxicity by Ferroptosis. Preprints2024, 2024041891. https://doi.org/10.20944/preprints202404.1891.v1
APA Style
Wang, X., Feng, J. H., Zeng, C. M., Zhang, Z. S., Cao, F. L., Zhang, W. H., Chen, J. X., Mao, Y., & Young, D. J. (2024). [Fe<sup>III</sup>Cl(TMPPH<sub>2</sub>)][Fe<sup>III</sup>Cl<sub>4</sub>]<sub>2</sub>: A Stand-Alone Molecular Nanomedicine that Induces High Cytotoxicity by Ferroptosis. Preprints. https://doi.org/10.20944/preprints202404.1891.v1
Chicago/Turabian Style
Wang, X., Yiming Mao and David James Young. 2024 "[Fe<sup>III</sup>Cl(TMPPH<sub>2</sub>)][Fe<sup>III</sup>Cl<sub>4</sub>]<sub>2</sub>: A Stand-Alone Molecular Nanomedicine that Induces High Cytotoxicity by Ferroptosis" Preprints. https://doi.org/10.20944/preprints202404.1891.v1
Abstract
Developing clinically meaningful nanomedicines for cancer therapy requires the drugs to be effective, safe, simple, cheap, and easy to store. In the present work, we report that a simple cationic Fe(III)-rich salt of [FeIIICl(TMPPH2)][FeIIICl4]2 (Fe-TMPP) exhibits a superior anticancer performance toward a broad spectrum of cancer cell lines, including breast, colorectal cancer, liver, pancreatic, prostate, and gastric cancers, with half maximal inhibitory concentration (IC50) values in the range of 0.098−3.97 μM (0.066−2.68 μg mL−1), and comparable to the best-reported medicines. Fe-TMPP can forms stand-alone nanoparticles in water without the need for extra surface modification or organic-solvent-assisted antisolvent precipitation. Critically, Fe-TMPP is TME-responsive (TME = tumor microenvironment), and can only elicit its function in the TME with overexpressed H2O2, converting H2O2 to the cytotoxic •OH to oxidize the phospholipid of the cancer cell membrane, causing ferroptosis, a programmed cell death process of cancer cells.
Keywords
single-molecular nanomedicine; porphyrin ligand; chemodynamic therapy; ferroptosis; breast cancer therapy
Subject
Chemistry and Materials Science, Inorganic and Nuclear Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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