PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol Loaded Nanostructured Lipid Carriers
Version 1
: Received: 17 April 2024 / Approved: 17 April 2024 / Online: 17 April 2024 (13:05:31 CEST)
How to cite:
Santonocito, D.; Puglia, C.; Montenegro, L. Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol Loaded Nanostructured Lipid Carriers. Preprints2024, 2024041166. https://doi.org/10.20944/preprints202404.1166.v1
Santonocito, D.; Puglia, C.; Montenegro, L. Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol Loaded Nanostructured Lipid Carriers. Preprints 2024, 2024041166. https://doi.org/10.20944/preprints202404.1166.v1
Santonocito, D.; Puglia, C.; Montenegro, L. Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol Loaded Nanostructured Lipid Carriers. Preprints2024, 2024041166. https://doi.org/10.20944/preprints202404.1166.v1
APA Style
Santonocito, D., Puglia, C., & Montenegro, L. (2024). Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol Loaded Nanostructured Lipid Carriers. Preprints. https://doi.org/10.20944/preprints202404.1166.v1
Chicago/Turabian Style
Santonocito, D., Carmelo Puglia and Lucia Montenegro. 2024 "Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol Loaded Nanostructured Lipid Carriers" Preprints. https://doi.org/10.20944/preprints202404.1166.v1
Abstract
To improve efficacy and safety of sunscreen emulsions, UV‐filter skin permeation could be kept as low as possible by reducing UV‐filter content or changing emulsion composition. In this work, different lipid phase ratio (12, 14 and 16% w/w) were assessed for their ability to affect the technological and sensory properties of O/W emulsions in which bemotrizinol (BMTZ), a broad spectrum sunscreen agent, was incorporated free or loaded into nanostructured lipid nanocarriers (NLC) to reduce its release from the vehicle and, hence, its skin permeation. The following technological properties were evaluated in vitro by suitable methodologies: spreadability, viscosity, pH, occlusion factor, BMTZ release, sun protection factor (SPF). Sensory attributes were assessed by trained panelists in three different phases: before/during pick‐up, rub‐in, after application. Raising the lipid phase ratio led to an increase of viscosity and to a corresponding drop of spreadability while the incorporation of BMTZ‐loaded NLC determined a decrease of occlusion factor and an increase of SPF. No BMTZ release was observed from all emulsions. Sensory attributes were mainly affected by lipid phase ratio. These results suggest that lipid phase ratio and BMTZ incorporation into NLC could contribute to determine technological and sensory properties of O/W emulsions.
Keywords
bemotrizinol; emulsions; sensory evaluation; UV-filters; lipid nanoparticles; in vitro SPF
Subject
Public Health and Healthcare, Other
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
